SML0393

QNZ46

≥98% (HPLC)

• 同義詞: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
• 經驗公式（希爾表示法）: C₂₄H₁₇N₃O₆
• CAS號碼: 1237744-13-6
• 分子量：: 443.41
• MDL號碼: MFCD22666391
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825390
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL (warmed; clear solution)
• 儲存溫度: room temp
• SMILES 字串: COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O
• InChI: 1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
• InChI 密鑰: GNLVJIICVWDSNI-LFYBBSHMSA-N

描述

生化／生理作用

QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC₅₀ values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

特點和優勢

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable