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Merck
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重要文件

SML0381

Sigma-Aldrich

ALLO-1

≥98% (HPLC)

同義詞:

3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-Imidazolidinedione

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About This Item

經驗公式(希爾表示法):
C17H15ClN2O2
CAS號碼:
分子量::
314.77
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

CC1N(Cc2ccccc2)C(=O)N(C1=O)c3ccc(Cl)cc3

InChI

1S/C17H15ClN2O2/c1-12-16(21)20(15-9-7-14(18)8-10-15)17(22)19(12)11-13-5-3-2-4-6-13/h2-10,12H,11H2,1H3

InChI 密鑰

GHAJNZREWTZYQJ-UHFFFAOYSA-N

生化/生理作用

ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo, including D473H SMO mutant. ALLO-1 binds to a different domain of Smo than other known Smo ligands.
ALLO-1 is a Smoothened (Smo) antagonist that inhibits both wild-type and mutant Smo.

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Miyuki Sato et al.
Nature cell biology, 20(1), 81-91 (2017-12-20)
In Caenorhabditis elegans embryos, paternally provided organelles, including mitochondria, are eliminated by a process of selective autophagy called allophagy, the mechanism by which mitochondrial DNA is inherited maternally. However, it remains unclear how paternal organelles are recognized and targeted for

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