SML0300

Aib-1 trifluoroacetate salt

≥98% (HPLC)

• 同義詞: Tyr-Aib-Trp-Phe trifluoroacetate salt
• 經驗公式（希爾表示法）: C₃₃H₃₇N₅O₆ · xC₂HF₃O₂
• CAS號碼: 1334763-90-4
• 分子量：: 599.68 (free base basis)
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329825306
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: lyophilized solid
• 顏色: white to beige
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• SMILES 字串: OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1
• InChI 密鑰: NELSAMPJZPTPEG-MDQBHWJISA-N

描述

生化／生理作用

Aib-1 is an inhibitor of β-Amyloid oligomerization.

Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable