推薦產品
化驗
≥95%
形狀
powder
光學活性
[α]/D +30 to +40° (c=1; CH2Cl2)
顏色
white to beige
溶解度
DMSO: >10 mg/mL (warmed)
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@]1(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]3C)OC(=O)CO
InChI
1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1
InChI 密鑰
ZRZNJUXESFHSIO-BKUNHTPHSA-N
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生化／生理作用
Pleuromutilin is a diterpene that acts against gram positive bacteria and mycoplasm. It is present in Pleurotus mutilus and Pleurotus passecherianus. Pleuromutilin exhibits its antibacterial action by interfering with the prokaryotic 70S ribosomal subunit and inactivates initiation complex. Pleuromutilin is useful in treating mycoplasma infections in animals.[1]
Pleuromutilin is an antibiotic natural product that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase center and inhibiting peptide bond formation.
Pleuromutilin is an antibiotic natural product that inhibits bacterial protein synthesis.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The enterococcal ABC transporter gene lsa(E) confers combined resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
Sarah Wendlandt et al.
The Journal of antimicrobial chemotherapy, 68(2), 473-475 (2012-10-11)
James E Ross et al.
Journal of clinical microbiology, 50(10), 3361-3364 (2012-07-21)
MIC and disk diffusion quality control (QC) ranges were established for two new pleuromutilin antimicrobials (BC-3205 and BC-3781) in an eight-laboratory study performed according to Clinical and Laboratory Standards Institute M23-A3 guidelines. Staphylococcus aureus ATCC 29213 and 25923, Streptococcus pneumoniae
A dialdehyde cyclization cascade: an approach to pleuromutilin.
Matthew D Helm et al.
Angewandte Chemie (International ed. in English), 48(49), 9315-9317 (2009-11-11)
Izabela Karpiuk et al.
Przeglad epidemiologiczny, 66(4), 567-573 (2012-01-01)
Development of new mechanisms of resistance and relatively easy and fast transferring of resistance genes between cells have resulted in emergence of large number of multi-drug resistant bacteria in recent years. Therefore, it is important to intensively search for new
Lykke H Hansen et al.
Antimicrobial agents and chemotherapy, 56(7), 3563-3567 (2012-05-02)
The cfr gene encodes the Cfr methyltransferase that methylates a single adenine in the peptidyl transferase region of bacterial ribosomes. The methylation provides resistance to several classes of antibiotics that include drugs of clinical and veterinary importance. This paper describes
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