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Merck
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Key Documents

SML0022

Sigma-Aldrich

IMB-10

≥98% (HPLC)

同義詞:

3-(2-methylphenyl)-5-(3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone

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About This Item

經驗公式(希爾表示法):
C19H15NOS2
CAS號碼:
分子量::
337.46
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

DMSO: ≥25 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cc1ccccc1N2C(=S)S\C(=C\C=C\c3ccccc3)C2=O

InChI

1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+

InChI 密鑰

UYZLENPCNZVWQZ-QHMSGILQSA-N

應用

IMB-10 may be used to study integrin-mediated signaling in tumor cells.

生化/生理作用

IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.
IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


分析證明 (COA)

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Juho Suojanen et al.
Anticancer research, 27(6B), 3775-3781 (2008-01-30)
Leukocyte immunomodulation has great clinical potential as a therapy of inflammatory conditions and cancer. We have recently developed leukocyte alphaMbeta2 integrin targeting small molecule (IMB-10) capable of inhibiting leukocyte migration and recruitment in vitro and in vivo. The purpose of

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