推薦產品
品質等級
化驗
≥95% (HPLC, NMR)
形狀
powder
儲存條件
desiccated
顏色
white to tan
溶解度
H2O: ≥25 mg/mL
起源
Daiichi-Sankyo
運輸包裝
wet ice
儲存溫度
−20°C
SMILES 字串
O.Cl.Cl.C[C@@H]1O[C@@]2(CS1)CN3CC[C@H]2CC3.C[C@@H]4O[C@@]5(CS4)CN6CC[C@H]5CC6
InChI
1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m11.../s1
InChI 密鑰
ZSTLCHCDLIUXJE-GMLJRNIPSA-N
應用
Cevimeline hydrochloride hemihydrate may be used in cell signaling studies.
生化／生理作用
Cevimeline is a muscarinic M1 and M3 receptor agonist.
Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth.
特點和優勢
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
Hirotaka Ueda et al.
The journal of medical investigation : JMI, 56 Suppl, 267-269 (2009-01-01)
Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly stimulates the peripheral mAChRs of the salivary glands. Since cevimeline is distributed in the brain after its oral administration, it is possible that it
Kentaro Ono et al.
The journal of medical investigation : JMI, 56 Suppl, 375-375 (2009-01-01)
Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory suggested that pilocarpine-induced salivation from the parotid gland is greater than that
文章
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
DISCOVER Bioactive Small Molecules for Neuroscience
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