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Merck
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重要文件

SCP0169

Sigma-Aldrich

HIV-1 Tat Peptide

HIV-TAT (48-57)
1 of 1 reviewers received a sample product or took part in a promotion

≥95% (HPLC), lyophilized powder

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About This Item

經驗公式(希爾表示法):
C65H124N34O13
分子量::
1589.90
分類程式碼代碼:
12352202
NACRES:
NA.32
暫時無法取得訂價和供貨情況

產品名稱

HIV-TAT (48-57),

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥55%

儲存條件

protect from light

儲存溫度

−20°C

Amino Acid Sequence

Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-NH2

一般說明

人类免疫缺陷病毒(HIV)-转录反式激活因子(Tat)是一种调节蛋白,由 HIV-1 的 Tat 基因编码。Tat 由两个外显子、高度保守区域和亚型特异性区域组成。[1]

生化/生理作用

人类免疫缺陷病毒(HIV)-转录反式激活因子(Tat)参与HIV相关并发症的发病机理。Tat 蛋白还与 HIV 相关的心功能障碍有关。[1]HIV-TAT(48-57)用于促进合成肽的内化。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Yanan Jiang et al.
Journal of translational medicine, 16(1), 121-121 (2018-05-10)
The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which
S-M Lee et al.
Clinical and experimental immunology, 161(3), 504-511 (2010-07-22)
The immune receptor expressed on myeloid cells 1 (IREM-1) has been known to regulate the activities of myeloid cells through its immunoreceptor tyrosine-based inhibition motifs (ITIMs) in its intracellular region. In order to investigate its effect on macrophage activation, a
S-M Lee et al.
Clinical and experimental immunology, 167(3), 438-446 (2012-02-01)
The immune receptor expressed on myeloid cells 1 (IREM-1/CD300F) has been shown to inhibit various inflammatory processes in myeloid cells, such as macrophages and mast cells. IREM-1 exerts its inhibitory effect through its intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). In

Questions

Reviews

1 of 1 reviewers received a sample product or took part in a promotion

Active Filters

    • Review 1
    • Votes 3
    1 out of 5 stars.

    Purchase a different product

    Quite disappointed in this product. For one, they do not provide any information on reconstitution of this lyophilized powder, not even whether to use dH20 or not. Additionally, please look closely at the 3 cited papers that allegedly used this product. One is a review that didn't actually use the product, and the other two are from the same lab that published what looks to be the same experiment twice, but without sufficient methodology. They list that, "Fusion proteins containing ITIMs and HIV-TAT48–57 and its negative control containing only HIV-TAT48–57 were custom-designed and synthesized by Peptron Inc. (Daejeon, Korea)" which is not this product? Additionally, their only methodology in terms of use does not include reconstitution, merely this sentence hidden below a figure, "Cells were pre-treated with 5 µM of TAT, TAT–YADL, TAT–YVTM, TAT–YASL, TAT–YCNM or TAT–YSTI for 30 min before stimulation with 1 µg/ml of lipopolysaccharide (LPS) for 24 h."

    When I contacted a rep about my concerns they said they couldn't help with reconstitution instructions and I should have checked to see if they had instructions before purchasing.... a less than stellar response. Save yourself the time, money, and hassle and find a different product.

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for taking the time to leave a review. We are sorry to hear that your experience did not meet expectations. Our Technical Service team has reached out to you with additional resources in effort to resolve this issue. We apologize for any inconvenience this may have caused.

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