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SAB4503879

Sigma-Aldrich

Anti-phospho-HSL (pSer552) antibody produced in rabbit

affinity isolated antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 116 kDa

物種活性

mouse, rat, human

濃度

~1 mg/mL

技術

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer552)

基因資訊

human ... LIPE(3991)

相關類別

一般說明

Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. It is an intracellular lipase with substrates as triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. HSL is mapped to human chromosome 19q13.

免疫原

The antiserum was produced against synthesized peptide derived from human HSL around the phosphorylation site of Ser552.

Immunogen Range: 518-567

應用

Anti-HSL antibody has been used in western blotting.

生化/生理作用

Hormone sensitive lipase (HSL) plays an important role in lipolysis. Lack of HSL results in histologic abnormalities in white adipose tissue and an increase in macrophage infiltration.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Progesterone-induced down-regulation of hormone sensitive lipase (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis
Stelmanska E, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 147, 31-39 (2015)
Identification of microdeletions spanning the Diamond-Blackfan anemia locus on 19q13 and evidence for genetic heterogeneity
Gustavsson P, et al.
American Journal of Human Genetics, 63(5), 1388-1395 (1998)
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes
Albert JS, et al.
The New England Journal of Medicine, 370(24), 2307-2315 (2014)
Shanhong Fang et al.
Molecular medicine (Cambridge, Mass.), 29(1), 33-33 (2023-03-16)
Caveolin-1 has been predicted, based on RNA transcriptome sequencing, as a key gene in rotator cuff tear (RCT) and it is related to fatty infiltration. This study aims to elucidate the upstream and downstream mechanism of Caveolin-1 in fatty infiltration

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