推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 33 kDa
物種活性
rat, mouse, human
濃度
~1 mg/mL
技術
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCND1(595)
一般說明
Anti-CYCLIN D1 antibody detects endogenous levels of total CYCLIN D1 protein.
The CCND1 (cyclin D1) gene is mapped to human chromosome 11q13.3.
免疫原
The antiserum was produced against synthesized peptide derived from human Cyclin D1.
Immunogen Range: 246-295
Immunogen Range: 246-295
應用
Anti-CYCLIN D1, C-Terminal antibody produced in rabbit has been used in western blotting analysis.[1]
生化／生理作用
CCND1 (cyclin D1) regulates cell cycle by mediating the G1 to S phase transition. The gene gets activated by β-catenin and participates in the process of tumor formation. Upregulation of the gene is observed in cancer such as lung, breast, colon, hematopoietic and prostate carcinomas, and promotes contact independent cell growth. Variation in CCND1 contributes to increased occurrence of colorectal cancer.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Tumor suppressor role of microRNA-1296 in triple-negative breast cancer.
Phan B
Oncotarget, 7(15), 19519-19530 (2016)
Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects.
Lanza C
Cell Cycle, 15(10), 1363-1375 (2016)
The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis.
Xie M
Medicine, 96(42), 1-9 (2017)
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Hui AB
Cancer Research, 65(18), 8125-8133 (2005)
Kai Fu et al.
eLife, 5, 1-12 (2016-12-21)
Previously we reported that Src-associated-substrate-during-mitosis-of-68kDa (Sam68/KHDRBS1) is pivotal for DNA damage-stimulated NF-κB transactivation of anti-apoptotic genes (Fu et al., 2016). Here we show that Sam68 is critical for genotoxic stress-induced NF-κB activation in the γ-irradiated colon and animal and that
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