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Merck
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SAB4500352

Sigma-Aldrich

Anti-Histone H3 antibody produced in rabbit

affinity isolated antibody

同義詞:

H3/a, H3/c, H3/d, H3/f, H3/h

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 15 kDa

物種活性

human, rat, mouse

濃度

~1 mg/mL

技術

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... HIST1H3A(8350)

一般說明

Anti-Histone H3 Antibody detects endogenous levels of total Histone H3 protein.
Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). Histone H3 is located on human chromosome 6p22.

免疫原

The antiserum was produced against synthesized peptide derived from human Histone H3.

Immunogen Range: 1-50

應用

Anti-Histone H3, N-Terminal antibody has been used in western blotting and enzyme-linked immunosorbent assay (ELISA).

生化/生理作用

Histone proteins are basic building blocks of chromatin. Histone H3 K27M mutations in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that “drive” chromatin condensation.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Histone Demethylation and Toll?like Receptor 8?Dependent Cross?Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra?2.
Ciechomska M, et al.
Arthritis and Rheumatism, 68(6), 1493-1504 (2016)
Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy.
Chen Y, et al.
Oncotarget, 7(47), 76508-76508 (2016)
Parissa C Monem et al.
PLoS genetics, 19(1), e1010577-e1010577 (2023-01-11)
As ribosomes translate the genetic code, they can encounter a variety of obstacles that hinder their progress. If ribosomes stall for prolonged times, cells suffer due to the loss of translating ribosomes and the accumulation of aberrant protein products. Thus
Omar Ramírez-Nuñez et al.
Journal of neurochemistry, 158(2), 482-499 (2021-04-28)
Nucleocytosolic transport, a membrane process, is impaired in motor neurons in amyotrophic lateral sclerosis (ALS). This study analyzes the nuclear lipidome in motor neurons in ALS and examines molecular pathways linked to the major lipid alterations. Nuclei were obtained from
Yongbiao Chen et al.
Oncotarget, 7(47), 76508-76522 (2016-10-30)
Liver ischemia and reperfusion (I/R) injury is characterized by defective liver autophagy accompanied by alterations to the endogenous defense system. Dihydromyricetin (DHM) is a natural flavonoid that demonstrates a wide range of physiological functions, and has been implicated as a

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