SAB4300694

Anti-TIF1β antibody produced in rabbit

affinity isolated antibody

• 同義詞: Anti-KAP1, Anti-RNF96
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: ~110 kDa
• 物種活性: monkey, human
• 濃度: 1 mg/mL
• 技術: western blot: 1:500-1:1000
• 同型: IgG
• 免疫原序列: (L-S-G-G-P)
• NCBI登錄號: NM_005762.2
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... TRIM28(10155)

描述

一般說明

The antibody detects endogenous level of total TIF1β protein.

免疫原

Peptide sequence around aa. 827-831 (L-S-G-G-P), according to the protein NP_005753.1

特點和優勢

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標靶描述

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ′Lys-9′ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ′Lys-9 and ′Lys-14′ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable