推薦產品
生物源
rabbit
共軛
peroxidase conjugate
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
描述
Research area: Microbiome
形狀
lyophilized powder
分子量
25-30 kDa
物種活性
Staphylococcus aureus
濃度
~4 mg/mL
技術
direct ELISA: 1:2,000-1:4,000 (recommended using 1 μg/ml Staphylococcal Enterotoxin A for coating.)
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
Staphylococcus aureus ... sea(22112712)
一般說明
Staphylococcus aureus is a Gram positive bacterium, that cause diseases in human population including food poisoning and toxic shock syndrome. S. aureus expresses several secreted virulence factors, such as various enzymes, cytotoxins, exotoxins, and exfoliative toxins. Exotoxins include more than 20 serologically classified staphylococcal enterotoxins (SEs), the best characterize are the SEs A, B through V and toxic shock syndrome toxin-1 (TSST-1), these enterotoxins are similar in activity, sequence, structure and molecular weight (~25-30 kDa).
Mainly SEA but also SEB are known as superantigens due to their ability to bind class II MHC molecules on antigen presenting cells and stimulate extensive T-cells activation followed by massive cytokine release leading to an acute toxic shock.
SE proteins have a significant resistance to heat and acid, it is also resistant to gastrointestinal proteases including pepsin, trypsin, rennin and papain. Thus, killing the S. aureus bacteria may not be sufficient to eliminate these superantigens risk from causing food poisoning.
As described in various researches, detection of SEA contamination is a major challenge in the food industry, including milk and cooked food products.
SEA high affinity to MHC class II receptors on antigen presenting cells and tissues, followed by the excessive systemic immune activation, was applied in attempts to use bispecific antibodies (BsAbs) genetically fused to SEA as a T-cell stimulator. The SEA activation resulted in a non-specific activation of MHC class II-positive tissues which causes side-effects. Mutated SEA, D227A was developed to reduce the adverse effects for directing activated T-cells toward tumor cells.
Mainly SEA but also SEB are known as superantigens due to their ability to bind class II MHC molecules on antigen presenting cells and stimulate extensive T-cells activation followed by massive cytokine release leading to an acute toxic shock.
SE proteins have a significant resistance to heat and acid, it is also resistant to gastrointestinal proteases including pepsin, trypsin, rennin and papain. Thus, killing the S. aureus bacteria may not be sufficient to eliminate these superantigens risk from causing food poisoning.
As described in various researches, detection of SEA contamination is a major challenge in the food industry, including milk and cooked food products.
SEA high affinity to MHC class II receptors on antigen presenting cells and tissues, followed by the excessive systemic immune activation, was applied in attempts to use bispecific antibodies (BsAbs) genetically fused to SEA as a T-cell stimulator. The SEA activation resulted in a non-specific activation of MHC class II-positive tissues which causes side-effects. Mutated SEA, D227A was developed to reduce the adverse effects for directing activated T-cells toward tumor cells.
免疫原
Purified toxin from Staphylococcus aureus, (This toxin is coded by a bacteriophage).
應用
The antibody may be used in various immunochemical techniques including ELISA.
外觀
Supplied as a lyophilized powder.
其他說明
In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.
免責聲明
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
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