推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
形狀
buffered aqueous solution
物種活性
human
濃度
~1 mg/mL
技術
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CHGA(1113)
一般說明
CHGA (chromogranin A) is a granin family acidic glycoprotein. It resides in endocrine and neuroendocrine cells, where it is localized to secretory dense-core granules which store peptide hormones. It is a predominant protein of the chromaffin cell secretory granules.
免疫原
synthetic peptide corresponding to the GR-44 peptide in the C-terminal region of human Chromogranin-A , conjugated to KLH.
應用
Anti-Chromogranin A antibody produced in rabbit has been used in immunohistochemistry.
生化／生理作用
CHGA (chromogranin A) is secreted in abnormal levels by neoplastic neuroendocrine cells, which might be linked with tumor growth and progression, as it might influence the different components of tumor stroma. It is a highly sensitive and specific biomarker for the diagnosis of NETs (neuroendocrine tumors). CHGA is processed to produce catestatin (CST), vasostatin-I, serpinin and pancreastatin (PST), which function as metabolic or cardiovascular-regulatory peptides. As this protein is co-stored and co-released with catecholamines, it plays an essential role in production of catecholamine storage vesicles. It functions as a circulating biomarker for gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) patients.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jibo Hu et al.
Oncology letters, 13(4), 2186-2190 (2017-04-30)
Nonfunctioning pancreatic neuroendocrine carcinoma (NPNEC) is a poorly differentiated neuroendocrine carcinoma and a rare type of pancreatic cancer. Computed tomography (CT)-based imaging is currently the most effective method for diagnosing and classifying NPNEC. The present study investigated the clinical features
Diagnostic value of circulating chromogranin a for neuroendocrine tumors: a systematic review and meta-analysis.
Yang X et al
PLoS ONE, 10(4), e0124884-e0124884 (2015)
A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population.
Choi Y et al
Endocrine Journal, 62(9), 797-804 (2015)
Chromogranin A as a marker for diagnosis, treatment, and survival in patients with gastroenteropancreatic neuroendocrine neoplasm.
Wang YH et al
Medicine, 93(27), e247-e247 (2014)
A comparison of three chromogranin A assays in patients with neuroendocrine tumours.
Hoej LB et al
Journal of Gastrointestinal and Liver Diseases : JGLD, 23(4), 419-424 (2014)
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