SAB4200551

Anti-MST1R antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 同義詞: Anti-CD136, Anti-CDw136, Anti-MST1R variant RON30, Anti-MST1R variant RON62, Anti-Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), Anti-PTK8, Anti-PTK8 protein tyrosine kinase 8, Anti-RON, Anti-RON variant E2E3, Anti-c-met-related tyrosine kinase, Anti-macrophage-stimulating protein receptor, Anti-p185-Ron
• 分類程式碼代碼: 12352203
• NACRES: NA.44

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~170 kDa
• 物種活性: rat, human
• 濃度: ~1.0 mg/mL
• 技術: western blot: 2.5-5.0 μg/mL using whole extracts of human HT-29 cells.
• UniProt登錄號: Q04912
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MST1R(4486) ; rat ... Mst1r(300999)

描述

一般說明

Macrophage-stimulating protein receptor (MST1R) is a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. It is a heterodimer of disulfide-linked α- and β-subunits, generated by proteolytic cleavage of a single-chain precursor. MST1R is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung. It belongs to the MET receptor tyrosine kinase family. MST1R is located on the human chromosome at 3p21.31.

特異性

Anti-MST1R recognizes human MST1R.

免疫原

synthetic peptide corresponding to an internal region of human MST1R, conjugated to KLH. The corresponding sequence is identical in rat and differs by 2 amino acids in mouse.

應用

Anti-MST1R antibody produced in rabbit may be used in immunoblotting.

生化／生理作用

Macrophage-stimulating protein receptor (MST1R) takes part in tumorigenesis. MST1R along with MSP is involved in host defense. Mutation of MST1R is associated with carcinoma of the breast, bladder, lung, colon, prostate, ovary and pancreas. Increased levels of MST1R is observed in aggressive tumors with poor patient survival.

外觀

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

儲存和穩定性

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免責聲明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable