生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~55 kDa
物種活性
human
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
技術
indirect immunofluorescence: 1:10,000-1:20,000 using HEK-293T cells overexpressing human dystrobrevin-a variant 6
western blot: 1:5,000-1:10,000 using lysates of HEK-293T cells overexpressing human dystrobrevin-a variant 6
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... DTNA(1837)
一般說明
Dystrobrevin-α (α-DB or DTNA) belongs to the dystrobrevin (DB) subfamily of the dystrophin-related-protein family.α-DB is a component of the dystrophin-glycoprotein complex (DGC) that is located at the muscle sarcolemma and forms a transmembrane link between the cytoskeleton and the basal lamina. The DB family includes two isoforms α- and β-DB encoded by the different genes. α-DB is also abundantly expressed in developing neurons and in the adult central nervous system (CNS). The DTNA gene is located on the human chromosome at 18q12.1.
特異性
Anti-Dystrobrevin-α specifically recognizes human dystrobrevin-α.
免疫原
synthetic peptide corresponding to a sequence at the C-terminal region of human dystrobrevin-a (DTNA), conjugated to KLH
應用
Anti-Dystrobrevin-α antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
生化／生理作用
Dystrobrevin- α (α -DB) is involved in the formation and stability of synapses and the clustering of nicotinic acetylcholine receptors. Mutations in the DTNA gene are associated with congenital heart defects. Dystrobrevin is markedly reduced or absent in the sarcolemma of patients with Duchenne muscular dystrophy (DMD).
外觀
solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
儲存和穩定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Prenatal diagnosis of de novo interstitial deletions involving 5q23. 1-q23. 3 and 18q12. 1-q12. 3 by array CGH using uncultured amniocytes in a pregnancy with fetal interrupted aortic arch and atrial septal defect
Chen C P, et al.
Gene, 531(2), 496-501 (2013)
Dystrobrevins in muscle and non-muscle tissues
Rees M L J, et al.
Neuromuscular Disorders, 17(2), 123-134 (2007)
Function and genetics of dystrophin and dystrophin-related proteins in muscle
Blake D J, et al.
Physiological Reviews (2002)
Dystrobrevin deficiency at the sarcolemma of patients with muscular dystrophy
Metzinger L, et al.
Human Molecular Genetics, 6(7), 1185-1191 (1997)
T Haenggi et al.
Cellular and molecular life sciences : CMLS, 63(14), 1614-1631 (2006-05-20)
The dystrophin glycoprotein complex (DGC) is a multimeric protein assembly associated with either the X-linked cytoskeletal protein dystrophin or its autosomal homologue utrophin. In striated muscle cells, the DGC links the extracellular matrix to the actin cytoskeleton and mediates three
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