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Merck
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重要文件

SAB4200108

Sigma-Aldrich

Anti-TIN2 antibody, Mouse monoclonal

clone TIN30, purified from hybridoma cell culture

同義詞:

Anti-TERF1 (TRF1)-interacting nuclear factor 2, Anti-TIN2L, Anti-TINF2

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41
暫時無法取得訂價和供貨情況

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified from hybridoma cell culture

抗體產品種類

primary antibodies

無性繁殖

TIN30, monoclonal

形狀

buffered aqueous solution

分子量

antigen ~40 kDa

物種活性

human

包裝

antibody small pack of 25 μL

濃度

~1.0 mg/mL

技術

western blot: 0.5-1.0 μg/mL using HeLa cell extract

同型

IgG1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... TINF2(26277)

相關類別

一般說明

Monoclonal Anti-TIN2 (mouse IgG1 isotype) is derived from the hybridoma TIN-30 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human TIN-2, conjugated to keyhole limpet hemocyanin (KLH). The six shelterin subunits are: TRF1, TRF2, and POT1 which directly recognize the TTAGGG repeats, and TIN2, Rap1 and TPP1. TIN2 (TRF-1 interacting nuclear factor 2) is recruited to the telomere through the TRF homology (TRFH) domain of TRF1 and tethers TPP1/POT1 to TRF1 and TRF2.

應用

Monoclonal Anti-TIN2 antibody produced in mouse has been used in immunoblotting.

生化/生理作用

TIN2 (TRF-1 interacting nuclear factor 2) also connects TRF1 to TRF2 and this link contributes to the stabilization of TRF2 on telomeres. In addition, TIN2 has also been found to tether the telomeres to the nuclear matrix. Interestingly, this protein has also been found to be mutated in Dyskeratosis Congenita, a multi-system disorder which in its classical form is characterized by abnormalities of the skin, nails, and mucous membranes.

外觀

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres
Ye JZS, et al.
The Journal of Biological Chemistry, 279(45), 47264-47271 (2004)
A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix
Kaminker PG, et al.
Cell Cycle, 8(6), 931-939 (2009)
David Frescas et al.
Genes & development, 28(2), 153-166 (2014-01-23)
The progressive bone marrow failure syndrome dyskeratosis congenita (DC) is often caused by mutations in telomerase or the factors involved in telomerase biogenesis and trafficking. However, a subset of DC patients is heterozygous for mutations in the shelterin component TIN2.
Titia de Lange
Genes & development, 19(18), 2100-2110 (2005-09-17)
Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific proteins associates with this sequence and protects chromosome ends. By analogy to other chromosomal protein complexes such as condensin and cohesin

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