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Merck
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重要文件

SAB3500178

Sigma-Aldrich

Anti-LXR-A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-LXRA, Anti-Liver X receptor A, Anti-NR1H3, Anti-Nuclear receptor subfamily 1 group H member 3

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41
暫時無法取得訂價和供貨情況

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

predicted mol wt 44-49 kDa

物種活性

rat, human, mouse

技術

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... NR1H3(10062)

一般說明

The gene LXR α (liver X receptor α) is a member of LXRs that belong to the nuclear receptor superfamily. The encoded protein is expressed predominantly in macrophages, liver, intestine, kidney, lung and adipose tissue. The gene is mapped to human chromosome 11p11.2. The protein contains a DNA-binding domain that requires the ligand-binding domain to heterodimerize with a retinoid X receptor partner for its DNA-binding activity.

免疫原

LXR-A antibody was raised against a 15 amino acid peptide from near the amino terminus human LXR-A.

生化/生理作用

The gene LXR α (liver X receptor α) encodes a protein that plays an important role in the control of cholesterol homeostasis. LXRs have been found to regulate inflammatory response in macrophages. They are also involved in the regulation of cell proliferation.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

聯結

The action of this antibody can be blocked using blocking peptide SBP3500178.

外觀

Supplied in PBS with 0.02% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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存取文件庫

CCAR2 negatively regulates nuclear receptor LXRa by competing with SIRT1 deacetylase.
Sakurabashi A
The Journal of Steroid Biochemistry and Molecular Biology, 149, 80-88 (2015)
Liver x receptors in atherosclerosis and inflammation.
Im SS and Osborne TF
Circulation Research, 108, 996-1001 (2011)

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