生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NR4A1(3164)
一般說明
Nuclear receptor subfamily 4 group A member 1 (NR4A1) is a transcription factor expressed in thymocytes. It is part of an orphan nuclear receptor superfamily. The gene encoding this protein is localized on human chromosome 12.
免疫原
Synthetic 17 amino acid peptide from internal region of human NUR77. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Horse (100%); Gorilla, Dog, Bat, Panda (94%); Marmoset, Bovine (88%); Mouse, Rat (82%).
生化／生理作用
Nuclear receptor subfamily 4 group A member 1 (NR4A1) has a role in cell proliferation. It acts as an activator of mechanistic target of rapamycin (mTOR) signaling and regulates apoptosis. The protein modulates genes related to low oxidative stress and growth promotion. NR4A1 has been shown to be expressed in ovarian tumors.
特點和優勢
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外觀
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nuclear receptor subfamily 4, group A, member 1 inhibits extrinsic apoptosis and reduces caspase-8 activity in H2O2-induced human HUC-F2 fibroblasts.
Shimuzu Y
Redox Report (2015)
Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.
Ashouri JF and Weiss A
Journal of Immunology, 198(2) (2017)
Differential Copy Number Aberrations in Novel Candidate Genes Associated with Progression from In Situ to Invasive Ductal Carcinoma of the Breast
Shaoxi Liao
Genes Chromosomes Cancer (2012)
High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome.
Delgado E
Gynecologic Oncology, 141(2) (2016)
Lingli He et al.
Cell reports, 33(3), 108284-108284 (2020-10-22)
The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the
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