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SAB2500067

Sigma-Aldrich

Anti-Amphiphysin/AMPH antibody produced in goat

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-AMPH1, Anti-HGNC:471

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41
暫時無法取得訂價和供貨情況

生物源

goat

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human, rat, canine, mouse

技術

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... AMPH(273)

一般說明

AMPH (Amphiphysin) is a 128kD peripheral protein highly distributed in nervous system including many neurons, certain endocrine cell types, and spermatocytes. It exists as two isoforms having different molecular weights 128 and 108kD respectively, in breast cancer. In human, it is located on chromosome 7, region p13-p14. It is a member of amphiphysin family and consists of an SH3 domain.

免疫原

Peptide with sequence C-KRKDESRISKAE from the internal region of the protein sequence according to NP_001626.1; NP_647477.1.

應用

Anti-Amphiphysin/AMPH antibody produced in goat is suitable for western blot.

生化/生理作用

AMPH (Amphiphysin) is involved in several pleotropic functions including endocytosis, actin function, and cell growth control. It plays an important role in synaptic vesicle endocytosis of axon terminals. Alteration in AMPH gene is associated with heritable disorders of the nervous system, endocrine tissues and male fertility. It also has correlation with a rare neurologic autoimmune disease, paraneoplastic Stiff-Man syndrome. It is also involved in the neoplastic growth cone dynamics.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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訊號詞

Warning

危險聲明

防範說明

危險分類

Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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R Yamamoto et al.
Human molecular genetics, 4(2), 265-268 (1995-02-01)
Amphiphysin is a protein peripherally associated with synaptic vesicles. It is expressed in many neurons, certain endocrine cell types, and spermatocytes. Autoantibodies against amphiphysin occur in patients afflicted with a rare neurologic autoimmune disease, paraneoplastic Stiff-Man syndrome. To provide a
S Floyd et al.
Molecular medicine (Cambridge, Mass.), 4(1), 29-39 (1998-03-26)
Amphiphysin I is a 128 kD protein highly concentrated in nerve terminals, where it has a putative role in endocytosis. It is a dominant autoantigen in patients with stiff-man syndrome associated with breast cancer, as well as in other paraneoplastic

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