推薦產品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
48991 Da
物種活性
human
技術
flow cytometry: 1:10-1:50
immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... DDX39B(7919)
一般說明
BAT1, also known as UAP56 or DExD-box helicase 39B (DDX39B), is encoded in the central region of the major histocompatibility complex (MHC) on the short arm of human chromosome 6p21.33. It is a member of DEAD box family of RNA-binding proteins and is characterized with the nine conserved motifs including ATPase and RNA helicase motifs.
應用
ANTI-BAT1(C-TERMINAL) antibody produced in rabbit has been used in immunoprecipitation and western blotting.
生化／生理作用
BAT1/ UAP56 facilitates the binding of U2 small nuclear ribonucleoprotein (SnRP) to pre-mRNA. It also helps in the export of mRNA from the nucleus to the cytoplasm. Spliceosome RNA helicase BAT1 is implicated in adapting nucleic acid metabolism to cellular stress. BAT1 is implicated in the down-regulation of inflammation. The gene polymorphism might be associated with the development of allergic diseases such as bronchial asthma, allergic rhinitis, atopic dermatitis, food allergy, drug allergy and pollen allergy. Mutation in the gene may also lead to the development of urticaria and Quincke′s edema.
外觀
Supplied in PBS with 0.09% (W/V) sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
M B Freĭdin et al.
Molekuliarnaia biologiia, 45(3), 464-472 (2011-07-28)
Genome-wide association studies are currently considered as one of the most powerful tools to establishing the genetic basis of complex diseases. A number of such studies were carried out for allergic diseases; however, in Russian population this analysis has not
Hang Shi et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(51), 17628-17633 (2004-12-09)
Pre-mRNA splicing requires the function of a number of RNA-dependent ATPases/helicases, yet no three-dimensional structure of any spliceosomal ATPases/helicases is known. The highly conserved DECD-box protein UAP56/Sub2 is an essential splicing factor that is also important for mRNA export. The
Influenza Virus mRNA Trafficking Through Host Nuclear Speckles.
Mor A, et al.
Nature microbiology, 2016 (2016)
EunMi Juliana Jung et al.
Proteomics, 7(21), 3906-3918 (2007-10-09)
Ambient particulate matter (PM) induces adverse health effects through the ability of pro-oxidative chemicals to induce the production of oxygen radicals and oxidant injury. Utilizing a proteomics strategy involving 2-D DIGE, immunoblotting, and real-time PCR, we demonstrate that organic diesel
R J Allcock et al.
Genes to cells : devoted to molecular & cellular mechanisms, 6(5), 487-494 (2001-05-31)
BAT1 belongs to the DEAD-box family of RNA-binding proteins and is encoded in the central MHC. To determine whether it affects immune responses and hence diseases influenced by MHC haplotypes, U937, THP1 and Jurkat cells were stably transfected with anti-sense
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