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Merck
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文件

S8072

Sigma-Aldrich

Sertindole

≥97.5% (HPLC)

同義詞:

1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone

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About This Item

經驗公式（希爾表示法）:
C24H26ClFN4O
CAS號碼:
106516-24-9
分子量：:
440.94
MDL號碼:
MFCD00867749
分類程式碼代碼:
12352200
PubChem物質ID:
329824596
NACRES:
NA.77

化驗

≥97.5% (HPLC)

形狀

solid

顏色

off-white

溶解度

DMSO: >10 mg/mL
H2O: <2 mg/mL

起源

Abbott

儲存溫度

2-8°C

SMILES 字串

Fc1ccc(cc1)-n2cc(C3CCN(CC3)CCN4CCNC4=O)c5cc(Cl)ccc25

InChI

1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)

InChI 密鑰

GZKLJWGUPQBVJQ-UHFFFAOYSA-N

基因資訊

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , DRD2(1813)

應用

Sertindole was used to study the role of 5-HT2C receptor in antipsychotic-induced body weight gain in rats.3

生化／生理作用

Sertindole readily passes the blood-brain barrier and is metabolized into compounds that show greater affinity for 5-HT2 receptors and less for D2 receptors. It is an effective treatment agent for schizophrenia as it improves cognitive impairment.1 Sertindole also acts as antagonist to human cardiac potassium channel, HERG and produces prolonged QT interval.2
Sertindole is a 5-HT2 serotonin and D2 dopamine receptor antagonist and antipsychotic.

特點和優勢

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險分類

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析證明 (COA)

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Dominique H Holstein et al.
Journal of psychopharmacology (Oxford, England), 25(12), 1600-1613 (2011-09-06)
Sensory gating, indexed by P50 suppression, and sensorimotor gating, indexed by prepulse inhibition (PPI), are impaired in schizophrenia spectrum disorders. There is considerable evidence that schizophrenia patients treated with atypical antipsychotics exhibit relatively less gating deficits than do other patients
D Rampe et al.
The Journal of pharmacology and experimental therapeutics, 286(2), 788-793 (1998-08-08)
Acquired long QT syndrome is a side effect seen with some pharmacological agents, including antipsychotic drugs, and is associated with the development of ventricular arrhythmias. This syndrome is often caused by the blockade of repolarizing potassium channels the human heart.
Lowijs Perquin et al.
CNS drugs, 18 Suppl 2, 19-30 (2004-10-06)
Sertindole is a non-sedating atypical antipsychotic agent with high selectivity for dopaminergic neurons in the mesolimbic system. In pivotal clinical trials, sertindole has demonstrated significantly greater efficacy than placebo against both the positive and negative symptoms of schizophrenia. In addition
Tomasz Kos et al.
Psychopharmacology, 214(4), 911-921 (2010-12-17)
Cognitive deficits, including an impaired ability to shift perceptual attentional set, belong to the core features of schizophrenia, are associated with prefrontal cortical dysfunctions, and may involve glutamate NMDA receptors. Although phencyclidine disturbs cognitive flexibility, little is known about the
Anna Secher et al.
Neuroendocrinology, 91(2), 155-168 (2009-10-10)
Body weight gain is a common side effect of treatment with antipsychotics, but the mechanisms underlying this weight gain are unknown. Several factors may be involved in antipsychotic-induced body weight gain including the cannabinoid receptor 1 (CB(1)), the serotonin receptor
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