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重要文件

R103

Sigma-Aldrich

利坦丝林

powder

同義詞:

6-[2- [4-(双(4-氟苯基)亚甲基] -1-哌啶基]乙基] -7-甲基-5H-噻唑并[3,2-a]嘧啶-5-酮

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About This Item

經驗公式(希爾表示法):
C27H25F2N3OS
CAS號碼:
分子量::
477.57
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

形狀

powder

顏色

white

溶解度

methanol: >10 mg/mL
DMSO: >10.1 mg/mL
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
dilute aqueous base: insoluble

SMILES 字串

CC1=C(CCN2CCC(\CC2)=C(\c3ccc(F)cc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1

InChI

1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3

InChI 密鑰

JUQLTPCYUFPYKE-UHFFFAOYSA-N

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應用

利坦色林已用于行为测试[1],并用作 5-羟色胺 2A 受体(5-HT2A)受体拮抗剂。[2][3]

生化/生理作用

利坦色林是有效的 5-羟色胺 2A 受体(5-HT2A)羟色胺受体拮抗剂/反向激动剂,可穿过血脑屏障。[4]它调节 5-HT 2A 受体,并被认为具有抗帕金森作用。[1]利坦色林还通过调节情绪、认知和消极症状来影响精神分裂症。[5]
有效的 5-HT2A 5-羟色胺受体拮抗剂/反向激动剂,可穿越血脑屏障。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone
Hashimoto H, et al.
Journal of Neurochemistry, 110(2), 595-602 (2009)
Modulation by 5-HT2A receptors of aggressive behavior in isolated mice
Sakaue M, et al.
Japanese Journal of Pharmacology, 89(1), 89-92 (2002)
Xiaojun Jia et al.
Neuropharmacology, 62(2), 775-783 (2011-09-20)
The key role of the hypothalamic neuropeptides orexins in maintenance and promotion of arousal has been well established in normal mammalian animals, but whether orexins exert arousal effects under pathological condition such as coma was little studied. In this study
Agnieszka Pałucha-Poniewiera et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 1066-1074 (2010-06-22)
Behavioral studies show that modulation of the glutamatergic system might be an efficient way to achieve antidepressant activity. Among the group III metabotropic glutamate (mGlu) receptors, the mGlu7 receptor subtype seems to be the most promising target for potential antidepressants.
The 5-HT 2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex
Ruiu S, et al.
Molecular Psychiatry, 5(6), 673-673 (2000)

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