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S2812

Sigma-Aldrich

SNC80

≥98% (HPLC), solid

同義詞:

(+)-4-[(αR)-α-((2S,5R)-4-烯丙基-2,5-二甲基-1-哌嗪基)-3-甲氧基苄基]-N,N-二乙基苯甲酰胺, SNC 80, SNC-80

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About This Item

經驗公式（希爾表示法）:
C28H39N3O2
CAS號碼:
156727-74-1
分子量：:
449.63
MDL號碼:
MFCD00672673
分類程式碼代碼:
12352200
PubChem物質ID:
24278698
NACRES:
NA.77
暫時無法取得訂價和供貨情況

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

顏色

off-white

溶解度

DMSO: soluble

SMILES 字串

CCN(CC)C(=O)c1ccc(cc1)[C@H](N2C[C@H](C)N(CC=C)C[C@H]2C)c3cccc(OC)c3

InChI

1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27?/m0/s1

InChI 密鑰

KQWVAUSXZDRQPZ-QNWUEUMSSA-N

基因資訊

human ... OPRD1(4985)
mouse ... Oprd1(18386)
rat ... Oprd1(24613) , Oprm1(25601)

應用

给予大鼠SNC80以研究一氧化氮合酶在外周抗伤害感受机制中的作用。5

生化／生理作用

SNC80是δ阿片受体的高度选择性激动剂，但也与μ-δ阿片受体异聚体结合以在小鼠中产生镇痛作用。2它还充当抗抑郁药3，引起多巴胺相关行为并增强对精神刺激药的行为反应。4
SNC80是δ-阿片受体激动剂。

特點和優勢

《受体分类和信号转导》手册的 阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000136411
0000136412
0000134963
0000076505
0000076506

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Iness Charfi et al.
Cellular and molecular life sciences : CMLS, 71(8), 1529-1546 (2013-09-12)
Signaling bias refers to G protein-coupled receptor ligand ability to preferentially activate one type of signal over another. Bias to evoke signaling as opposed to sequestration has been proposed as a predictor of opioid ligand potential for generating tolerance. Here
Paul Chu Sin Chung et al.
Behavioural brain research, 278, 429-434 (2014-12-03)
The delta opioid receptor (DOR) has raised much interest for the development of new therapeutic drugs, particularly to treat patients suffering from mood disorders and chronic pain. Unfortunately, the prototypal DOR agonist SNC80 induces mild epileptic seizures in rodents. Although
Richard M van Rijn et al.
The Journal of pharmacology and experimental therapeutics, 335(1), 133-139 (2010-07-08)
Alcoholism and anxiety disorders have a huge impact on society and afflict 17.6 million and 40 million people in the United States, respectively. A strong comorbidity exists between alcoholism and anxiety disorders. Indeed, alcohol withdrawal-induced anxiety is a primary contributing
Matthew D Metcalf et al.
ACS chemical neuroscience, 3(7), 505-509 (2012-08-04)
Coexpressed and colocalized μ- and δ-opioid receptors have been established to exist as heteromers in cultured cells and in vivo. However the biological significance of opioid receptor heteromer activation is less clear. To explore this significance, the efficacy of selective
Katia Befort et al.
Psychopharmacology, 214(4), 967-976 (2010-12-25)
Response inhibition, a primary symptom of many psychiatric disorders, is mediated through a complex neuropharmacological network that involves dopamine, serotonin, glutamate, noradrenaline, and cannabinoid mechanisms. Recently, we identified an opioidergic contribution to response inhibition by showing that deletion of mu
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