RAB1127

小鼠PAI-1 ELISA试剂盒

for cell culture supernatants, plasma, and serum samples

• 分類程式碼代碼: 41116158
• NACRES: NA.32

屬性

• 物種活性: mouse, human
• 技術: ELISA: suitable
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 80 pg/ml
• 運輸包裝: wet ice
• 儲存溫度: −20°C

描述

一般說明

The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1. Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.

This ELISA antibody pair detects mouse and human PAI-1.

應用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生化／生理作用

PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.

其他說明

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

安全資訊

• 象形圖: GHS05
• 訊號詞: Warning
• 危險聲明: H290
• 防範說明: P234 - P390
• 危險分類: Met. Corr. 1
• 儲存類別代碼: 8A - Combustible corrosive hazardous materials
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable