R5030

Ridaifen-B

≥98% (HPLC), white, solid

• 同義詞: 1,1′-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis-pyrrolidine
• 經驗公式（希爾表示法）: C₃₄H₄₂N₂O₂
• CAS號碼: 886465-70-9
• 分子量：: 510.71
• MDL號碼: MFCD11114395
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329824031
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 存貨情形: not available in Japan
• 儲存條件: desiccated
• 顏色: white
• 溶解度: DMSO: ≥13 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: CC\C(c1ccccc1)=C(/c2ccc(OCCN3CCCC3)cc2)c4ccc(OCCN5CCCC5)cc4
• InChI: 1S/C34H42N2O2/c1-2-33(28-10-4-3-5-11-28)34(29-12-16-31(17-13-29)37-26-24-35-20-6-7-21-35)30-14-18-32(19-15-30)38-27-25-36-22-8-9-23-36/h3-5,10-19H,2,6-9,20-27H2,1H3
• InChI 密鑰: XQQWCGJGUHJSLR-UHFFFAOYSA-N

描述

生化／生理作用

Ridaifen-B (RID-B) is a novel tamoxifen (TAM) analog that significantly augments apoptosis-inducing effect of TAM in estrogen receptor (ER)-negatives cells.

Ridaifen-B (RID-B) is a novel tamoxifen (TAM) analog that significantly augments apoptosis-inducing effect of TAM in estrogen receptor (ER)-negatives cells. Ridaifen-B induces mitochondria-involved apoptosis in Jurkat cells, as evidenced by chromatin-condensed cells as well as downstream activation of caspases (caspase-3, -8 and -9) in a dose- and time-dependent manner. At 4 hours of incubation, IC50 for RID-B is 4 muM (30 muM for TAM). And at prolonged treatment of 48 hours, IC50 for RID-B is 0.1 muM. In a related report on the global anti-tumor activity, RID-B strongly inhibits 39 human cancer cells (JFCR 39), both ER-+ or ER-- at concentrations of equal or less than 1muM (e.g., at 0.38muM for SF-539 [central nervous system], at 0.58muM for HT-29 [colon], at 0.20muM for DMS114 [lung], at 0.21muM for LOX-IMVI [melanoma], and at 0.23muM for MKN74 [stomach]. The binding protein of RID-B that exerts the apoptosis events is currently under investigation.

特點和優勢

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H315,H318,H335
• 防範說明: P280 - P302 + P352 - P305 + P351 + P338 + P310
• 危險分類: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves