推薦產品
產品名稱
UK-5099, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
powder
顏色
yellow to tan
溶解度
DMSO: >20 mg/mL
儲存溫度
2-8°C
SMILES 字串
OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N
InChI
1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI 密鑰
BIZNHCWFGNKBBZ-JLHYYAGUSA-N
應用
生化/生理作用
UK-5099可诱导产生乳酸。[4]
UK-5099是线粒体丙酮酸转运蛋白的有效抑制剂。
UK-5099是线粒体丙酮酸转运蛋白的有效抑制剂。n大鼠心脏线粒体,UK-5099可抑制丙酮酸依赖性O2消耗,IC50 为50 nM。
特點和優勢
该化合物是细胞凋亡研究的推荐产品。点击此处,了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
從最近期的版本中選擇一個:
分析證明 (COA)
Lot/Batch Number
客戶也查看了
B J Dezube et al.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 14(1), 13-17 (1997-01-01)
Interleukin-6 (IL-6) may be important in the pathogenesis of HIV-1 because of its ability to induce HIV-1 expression in infected cells in vitro. Tenidap, a structurally and functionally novel antirheumatic drug affecting diverse biologic processes, has been shown to reduce
Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.
Y Hamon et al.
Blood, 90(8), 2911-2915 (1997-10-24)
The production of interleukin-1beta (IL-1beta), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1beta. Because of the heavy side effects
Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro
Zhong Y, et al.
Testing, 6(35), 37758-37758 (2015)
A P Halestrap et al.
The Biochemical journal, 223(3), 677-685 (1984-11-01)
The inhibitor of mitochondrial pyruvate transport alpha-cyano-beta-(1-phenylindol-3-yl)-acrylate was used to inhibit progressively pyruvate carboxylation by liver mitochondria from control and glucagon-treated rats. The data showed that, contrary to our previous conclusions [Halestrap (1978) Biochem. J. 172, 389-398], pyruvate transport could
Oleic acid stimulates glucagon-like peptide-1 release from enteroendocrine cells by modulating cell respiration and glycolysis
Clara R, et al.
Metabolism and Disease, 65(3), 8-17 (2016)
文章
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Active Filters
我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務