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重要文件

PZ0160

Sigma-Aldrich

UK-5099

≥98% (HPLC), powder, mitochondrial pyruvate carrier inhibitor

同義詞:

2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸, PF-1005023

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About This Item

經驗公式(希爾表示法):
C18H12N2O2
CAS號碼:
分子量::
288.30
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

UK-5099, ≥98% (HPLC)

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow to tan

溶解度

DMSO: >20 mg/mL

儲存溫度

2-8°C

SMILES 字串

OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N

InChI

1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+

InChI 密鑰

BIZNHCWFGNKBBZ-JLHYYAGUSA-N

應用

UK-5099已用于:
  • 在用于前列腺癌细胞系培养的Roswell公园纪念研究所(RPMI)1640培养基中用作线粒体丙酮酸阻滞剂,以减少丙酮酸向线粒体的运输[1]
  • 二甲基亚砜(DMSO)的储备液中,[2] 以研究抑制丙酮酸转运入线粒体对脂多糖激活的巨噬细胞促炎反应的影响[3]
  • 局部处理,以用于研究其对实验小鼠毛发周期诱导的作用[4]

生化/生理作用

UK-5099可诱导产生乳酸。[4]
UK-5099是线粒体丙酮酸转运蛋白的有效抑制剂。
UK-5099是线粒体丙酮酸转运蛋白的有效抑制剂。n大鼠心脏线粒体,UK-5099可抑制丙酮酸依赖性O2消耗,IC50 为50 nM。

特點和優勢

该化合物是细胞凋亡研究的推荐产品。点击此处,了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问sigma.com/discover-bsm

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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B J Dezube et al.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 14(1), 13-17 (1997-01-01)
Interleukin-6 (IL-6) may be important in the pathogenesis of HIV-1 because of its ability to induce HIV-1 expression in infected cells in vitro. Tenidap, a structurally and functionally novel antirheumatic drug affecting diverse biologic processes, has been shown to reduce
Y Hamon et al.
Blood, 90(8), 2911-2915 (1997-10-24)
The production of interleukin-1beta (IL-1beta), a powerful mediator of inflammation, is tightly regulated at several levels. However, in some pathologic conditions, a pharmacologic treatment is required to control the toxicity of excessive extracellular IL-1beta. Because of the heavy side effects
Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro
Zhong Y, et al.
Testing, 6(35), 37758-37758 (2015)
A P Halestrap et al.
The Biochemical journal, 223(3), 677-685 (1984-11-01)
The inhibitor of mitochondrial pyruvate transport alpha-cyano-beta-(1-phenylindol-3-yl)-acrylate was used to inhibit progressively pyruvate carboxylation by liver mitochondria from control and glucagon-treated rats. The data showed that, contrary to our previous conclusions [Halestrap (1978) Biochem. J. 172, 389-398], pyruvate transport could
Oleic acid stimulates glucagon-like peptide-1 release from enteroendocrine cells by modulating cell respiration and glycolysis
Clara R, et al.
Metabolism and Disease, 65(3), 8-17 (2016)

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Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

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