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PLA0011

Sigma-Aldrich

Rabbit anti-DNMT1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

同義詞:

ADCADN, AIM, CXXC-type zinc finger protein 9, CXXC9, DNA MTase HsaI, DNA methyltransferase HsaI, DNMT, Dnmt1, HSN1E, MCMT, m.HsaI

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41
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生物源

rabbit

品質等級

抗體表格

affinity purified immunoglobulin

抗體產品種類

primary antibodies

物種活性

human

技術

immunoprecipitation (IP): 2-4 μg/mg
western blot: 1:2000-1:10,000

登錄號

NP_001370.1

UniProt登錄號

運輸包裝

wet ice

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

rabbit ... DNMT1(1786)

免疫原

The epitope recognized by PLA0011 maps to a region between residue 700 and 750 of human DNA-Methyltranserase 1 using the numbering given in entry NP_001370.1 (GeneID 1786).

外觀

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

其他說明

DNA methyltransferase 1 (DNMT1) catalyzes the methylation of the 5′-cytosine in the dinucleotide sequence, CpG. DNMT1 is thought to be responsible for the regulation of methylation patterns that are important in development and influence gene expression in a time- and tissue-specific manner.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Clara Dees et al.
The Journal of clinical investigation, 130(5), 2347-2363 (2020-01-29)
Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an "autonomous," self-maintaining profibrotic phenotype

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