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重要文件

P8761

Sigma-Aldrich

丙磺舒

≥98% (NaOH, titration), powder, uricosuric agent

同義詞:

-(二丙基氨磺酰)苯甲酸

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About This Item

經驗公式(希爾表示法):
C13H19NO4S
CAS號碼:
分子量::
285.36
EC號碼:
MDL號碼:
分類程式碼代碼:
12161501
PubChem物質ID:
NACRES:
NA.77
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產品名稱

丙磺舒,

化驗

≥98% (NaOH, titration)

起源

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES 字串

CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O

InChI

1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)

InChI 密鑰

DBABZHXKTCFAPX-UHFFFAOYSA-N

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應用

丙磺舒已经用作:
  • 无酚红Hank组分′细胞内Ca2+-转移试验的缓冲液[1]
  • 钙敏感染料组分,用于钙动员研究[2]
  • Hank′平衡盐溶液(HBSS)试验缓冲液补充剂[3]

可用作有机阴离子转运蛋白MRP的抑制剂。

生化/生理作用

丙磺舒是尿酸排泄剂,可促进尿液[4]尿酸排除,减少尿酸盐再摄取。[5]它还能降低许多其他药物的肾小管分泌,提高药物血浆浓度。丙磺舒的抑制作用通过有机阴离子转运蛋白介导。已发现它可以用于治疗痛风。[5]丙磺舒可防止神经化学物质从脉络丛和薄壁细胞移动至血浆,从而控制大脑内的神经化学物质水平上升。[4]

特點和優勢

该化合物是ADME Tox研究推荐产品。点击此处 ,查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm
该化合物由Merck & Co., Inc.(美国新泽西州Kenilworth)开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单, 请单击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

防範說明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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The
Drugs of Abuse: Neurological Reviews and Protocols, 109-109 (2003)
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice
Tang X, et al.
Journal of Lipid Research, 55, 2389-2400 (2014)
Determining the potency and molecular mechanism of action of insurmountable antagonists.
Kenakin, T, et al.
Journal of Pharmacology and Experimental Therapeutics, 319, 710-723 (2014)
Probenecid, a gout remedy, inhibits pannexin 1 channels
Harris D, et al.
American Journal of Physiology. Cell Physiology, 295, C761?C767-C761?C767 (2008)
Agnes Leffler et al.
Biochemical pharmacology, 77(9), 1522-1530 (2009-05-12)
Tachykinin NK receptors (NKRs) differ to a large degree among species with respect to their affinities for small molecule antagonists. The aims of the present study were to clone NKRs from gerbil (NK2R and NK3R) and dog (NK1R, NK2R and

文章

Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.

Discover Bioactive Small Molecules for ADME/Tox

Questions

  1. What is the solubility and solution stability?

    1 answer
    1. The solubility specification was tested at 100 mg/ml in 1 M NaOH (refer to the specification sheet). Probenecid is soluble in chloroform, in dilute solutions of sodium hydroxide, then buffered to pH 7.4, and is nearly insoluble in water. It is also soluble in 1 M NaOH (50 mg/ml), producing a clear, colorless solution.

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