推薦產品
重組細胞
expressed in baculovirus infected insect cells
品質等級
化驗
≥95% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
~4.5 units/mg protein
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... PIK3CG(5294)
一般說明
Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.
生化／生理作用
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
單位定義
1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.
外觀
Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism
Serajee FJ, et al.
Journal of medical Genetics, 40 (2003)
The effect of pharmacological PI3Kγ inhibitor on eotaxin-induced human eosinophil functions.
Saito Y, et al.
Pulmonary Pharmacology & Therapeutics, 27, 164-169 (2014)
Genome-wide meta-analyses identifies 7 loci associated with platelet aggregation in response to agonists
Johnson AD, et al.
Nature Genetics, 42, 608-613 (2010)
Down-Regulation of PIK3CG, a Catalytic Subunit of Phosphatidylinositol 3-OH Kinase, by CpG Hypermethylation in Human Colorectal Carcinoma
Semba S, et al.
Clinical Cancer Research, 8, 3824-3831 (2002)
B Stoyanov et al.
Science (New York, N.Y.), 269(5224), 690-693 (1995-08-04)
Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by mammalian cell surface receptors and in the regulation of protein sorting in yeast. Receptors with intrinsic and associated tyrosine kinase activity recruit heterodimeric phosphoinositide-3 kinases that consist of p110
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