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Merck
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P8296

Sigma-Aldrich

5-磷酰核糖-1-焦磷酸酶 五钠盐

≥75% (HPLC)

同義詞:

α-D-核糖二磷酸5-磷酸 五钠盐, 5-磷酸-α-D-核糖基二磷酸酯, 5-磷酸核糖基1-焦磷酸酯 五钠盐, P-Rib-PP, PRPP 五钠盐

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About This Item

經驗公式(希爾表示法):
C5H8Na5O14P3
CAS號碼:
分子量::
499.98
Beilstein:
6043637
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:
NACRES:
NA.25

化驗

≥75% (HPLC)

形狀

powder

雜質

<18% water (Karl Fischer)

顏色

white

溶解度

water: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@H](O[C@@H]1COP(O)([O-])=O)OP([O-])(=O)OP([O-])([O-])=O

InChI

1S/C5H13O14P3.4Na/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13;;;;/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13);;;;/q;4*+1/p-4/t2-,3-,4-,5?;;;;/m1..../s1

InChI 密鑰

QZAPPJHVNYCTAX-CKJQBBATSA-J

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應用

五钠盐已被用于评估豚鼠空肠平滑肌细胞中毒蕈碱受体阳离子电流与内部钙之间的关系。 它也已被用于细菌细胞壁Mur D酶的生物合成抑制剂的研究中。

基底

核苷酸合成中磷酸核糖基转移酶的底物。

分析報告

纯度 ≥ 75%,基于使用乳清苷-5′-磷酸焦磷酸化酶和乳清苷-5′-磷酸脱羧酶混合酶的测定系统。

其他說明

为了全面了解我们针对客户研究提供的各种单糖产品,建议您访问我们的碳水化合物分类页面。

象形圖

Health hazard

訊號詞

Warning

危險聲明

防範說明

危險分類

STOT SE 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

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L D Gegnas et al.
Bioorganic & medicinal chemistry letters, 8(13), 1643-1648 (1999-01-05)
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
P Pacaud et al.
The Journal of physiology, 441, 477-499 (1991-09-01)
1. The action of carbachol, which activates muscarinic receptors, was studied in single patch-clamped cells where free internal calcium concentration in the cell (Cai2+) was estimated using the emission from the dye Indo-1. Cells were dialysed with potassium-free caesium solution
Nisreen Wahwah et al.
Scientific reports, 10(1), 19907-19907 (2020-11-18)
Cisplatin is a mainstay of cancer chemotherapy. It forms DNA adducts, thereby activating poly(ADP-ribose) polymerases (PARPs) to initiate DNA repair. The PARP substrate NAD+ is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced
Matthew Bratkowski et al.
Cell reports, 32(5), 107999-107999 (2020-08-07)
The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) and provide mechanistic insight into the tight regulation
Boyuan Wang et al.
Molecular cell, 80(1), 29-42 (2020-08-29)
(p)ppGpp is a nucleotide messenger universally produced in bacteria following nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several different enzymes, but the physiological significance of their inhibition is unknown. Here, we report the structural basis of

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