P2928

蕈青霉素

powder, ≥98% (HPLC)

• 經驗公式（希爾表示法）: C₂₇H₃₃NO₄
• CAS號碼: 57186-25-1
• 分子量：: 435.56
• MDL號碼: MFCD00083464
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24898374
• NACRES: NA.77

屬性

• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: faintly yellow
• 儲存溫度: 2-8°C
• SMILES 字串: CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C34C)C2=CC1=O
• InChI: 1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
• InChI 密鑰: ACNHBCIZLNNLRS-UBGQALKQSA-N

描述

一般說明

Paxilline is an indole diterpene metabolite produced by fungi. It has a functionalized pentacyclic core and is a template for the synthesis of a wide variety of derivatives.[1]

應用

Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells[2] and in myometrial cells of uterine samples.[3] Paxilline acts as an agonist and activates liver X receptor in atlantic salmon.[4]

生化／生理作用

Paxilline is a selective blocker of high-conductance Ca₂⁺-activated (Maxi-K) potassium channels.[5] It also blocks big potassium (BK) channels.[6]

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

其他說明

Major toxin in Penicillium paxilli

安全資訊

• 象形圖: GHS06,GHS05
• 訊號詞: Danger
• 危險聲明: H301 + H311 + H331,H315,H318,H335
• 防範說明: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges