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P1999

PEAQX 四钠水合物

Name: PEAQX 四钠 水合物
Brand: SIGMA

≥98% (HPLC)

同義詞:

NVP-AAM077 四钠水合物, [ [[(1S)-1-（4-溴苯基）乙基] 氨基]（1,2,3,4-四氢-2,3-二氧代-5-喹喔啉基）甲基] 膦酸四钠水合物

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About This Item

經驗公式（希爾表示法）:

C₁₇H₁₃BrN₃Na₄O₅P · xH₂O

CAS號碼:

459836-30-7

分子量：:

542.14 (anhydrous basis)

分類程式碼代碼:

12352200

PubChem物質ID:

329820113

NACRES:

NA.77

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DL-2-氨基-5-膦酰戊酸

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P5511

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蝇蕈醇

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S-(5′-腺苷)-L-甲硫氨酸氯化物二盐酸盐

GE17-1440-02

Ficoll^® Paque Plus

Sigma-Aldrich

69453

L-高半胱氨酸

Sigma-Aldrich

S5886

氯化钠

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

water: 10 mg/mL

儲存溫度

−20°C

SMILES 字串

[Na+].[Na+].[Na+].[Na+].[H]O[H].C[C@H](NC(c1cccc2nc([O-])c([O-])nc12)P([O-])([O-])=O)c3ccc(Br)cc3

InChI

1S/C17H17BrN3O5P.4Na.H2O/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;;1H2/q;4*+1;/p-4/t9-,17?;;;;;/m0...../s1

InChI 密鑰

SMGAGBKXHAHCGQ-VSYRWHDMSA-J

應用

PEAQX四钠水合物已被用作大鼠[1][2] 和小鼠的N-甲基-D-天冬氨酸 (NMDA) 受体 2A (NR2A) 拮抗剂。[3]

生化／生理作用

NMDA 受体拮抗剂。

PEAQX对N-甲基-D-天冬氨酸 (NMDA) 受体2A (NR2A) 的特异性高于对N-甲基-D-天冬氨酸 (NMDA) 受体 2B (NR2B) 的特异性，并诱导纹状体细胞凋亡。它在激活caspase-3方面的效力不如其立体异构体NVP-AAM007。[4]

特點和優勢

该化合物是受体分类及信号转导手册上谷氨酸受体（离子通道家族）页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

GHS07

訊號詞

Warning

危險聲明

H302,H315,H319,H335

防範說明

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number

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Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.

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Behavioural brain research, 250, 18-22 (2013-05-09)

Adolescents display high levels of interactions with peers relative to other age groups, with these interactions further enhanced by ethanol under some circumstances. Understanding of the neural mechanisms underlying these high levels of social interactions is important given that alcohol

Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodic short-term memory, especially working memory, but not long-term memory.

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Neurobiology of learning and memory, 155, 435-445 (2018-09-24)

The CA3 subregion of the hippocampus is important for rapid encoding, storage and retrieval of associative memories. Lesions and pharmacological inhibitions of hippocampal CA3 suggest that it is essential for different memories. However, how CA3 functions in spatial and episodic

The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.

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5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

Yves P Auberson et al.

Bioorganic & medicinal chemistry letters, 12(7), 1099-1102 (2002-03-23)

NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1A/2A over 1A/2B subunit composition was optimized, leading to (1RS,1'S)-PEAQX (9r), which

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Neuroscience, 163(4), 1181-1191 (2009-08-06)

The mechanism underlying phencyclidine (PCP)-induced apoptosis in perinatal rats and the development of schizophrenia-like behaviors is incompletely understood. We used antagonists for N-methyl-D-aspartate (NMDA) receptor subunit NR2A- and NR2B-containing NMDA receptor to test the hypothesis that the behavioral and apoptotic

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重要文件

PEAQX 四钠 水合物

≥98% (HPLC)

About This Item

推薦產品

屬性

品質等級

化驗

形狀

儲存條件

顏色

溶解度

儲存溫度

SMILES 字串

InChI

InChI 密鑰

描述

應用

生化／生理作用

特點和優勢

安全資訊

象形圖

訊號詞

危險聲明

防範說明

危險分類

標靶器官

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

個人防護裝備

文件

分析證明 (COA)

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PEAQX 四钠水合物