P0999

Anti-Potassium Channel K_v10.1 (EAG-1) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 同義詞: Anti-Ether-a-go-go K⁺ channel 1, Anti-KCNH1
• MDL號碼: MFCD08705506
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: lyophilized powder
• 物種活性: human, mouse, rat
• 技術: western blot: 1:200 using rat brain lysate and transfected cells HEK-K_V10.1.
• UniProt登錄號: O95259
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... KCNH1(3756) ; mouse ... Kcnh1(16510) ; rat ... Kcnh1(65198)

描述

一般說明

Human genome codes for 40 voltage-gated K⁺ channels (K_V). Voltage-gated-like ion channels (VGICs) are the third largest group of signaling molecules found in humans. K⁺ channels can be divided into four structural types based on their number of transmembrane regions and mode of activation, namely K_ir- the inwardly rectifying 2-transmembrane K⁺ channels, K_2P- 2-pore 4-transmembrane K⁺ channels, K_Ca- Ca²⁺-activated 6-transmembrane or 7-transmembrane K⁺ channels, and K_V- voltage-gated 6-transmembrane K⁺ channels. KCNH1 (potassium voltage-gated channel H1) is a K_V channel and is also known as K_V10.1. Like all K_V members, it is composed of four α-subunits with each containing six transmembrane α-helical segments, and a membrane-re-entering P-loop. These surround a central pore as homotetramers or heterotetramers. KCNH1 mRNA and protein are both abundantly found in the brain, though its peripheral tissue expression is restricted. This gene is localized to human chromosome 1q32.1.

特異性

Specific for K_V10.1 and does not cross react with K_V10.2.

免疫原

peptide GDPAKRKGWARFKDAC corresponding to residues 802-817 of rat K_V10.1. This sequence is identical in mouse and has 14/16 residues identical in human.

生化／生理作用

KCNH1 (potassium voltage-gated channel H1) initiates a slowly activating, non-inactivating K₊ current in a heterologous system. In skeletal muscles, it is expressed only during the phase when myoblasts exit the cell cycle and fuse, and thus, it plays an essential role in skeletal muscle development. This protein is found to be expressed in ∼70% human cancers, including gastric, mammary tumors, colon carcinoma, and sarcomas. This channel is implicated in neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes.

標靶描述

Potassium Channel K_v10.1 (EAG-1) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming α-subunit of a voltage-gated non-inactivating delayed rectifier potassium channel.

外觀

Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable