推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
off-white
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5
InChI
1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
InChI 密鑰
NVRXTLZYXZNATH-UHFFFAOYSA-N
生化／生理作用
PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events.[1] It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).[1]
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases.
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.
特點和優勢
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Beth Apsel et al.
Nature chemical biology, 4(11), 691-699 (2008-10-14)
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here
Zhihang Zhou et al.
Experimental cell research, 388(2), 111857-111857 (2020-01-24)
Bone resorption, caused by osteoclasts (OCs), is important to bone homeostasis. The abnormalities of bone resorption may induce a series of diseases, including osteoarthritis, osteoporosis and aseptic peri-implant loosening. The latest research developed,a novel tyrosine and phosphoinositide kinase dual inhibitor
文章
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