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Merck
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文件

N7764

Sigma-Aldrich

烟酸单核苷酸

同義詞:

Nicotinate mononucleotide

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About This Item

經驗公式(希爾表示法):
C11H14NO9P
CAS號碼:
分子量::
335.20
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.79

生物源

animal

化驗

≥98.0% (HPLC)

形狀

powder

技術

HPLC: suitable

顏色

white

儲存溫度

−20°C

SMILES 字串

OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O

InChI

1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)

InChI 密鑰

IUJWGLOJJKFASX-UHFFFAOYSA-N

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一般說明

烟酸单核苷酸(NaMN)是在存在磷酸核糖基转移酶(NaPRT)的情况下,由烟酸5-磷酸核糖基-1-焦磷酸(PRPP)通过Preiss-Handler途径形成的。

應用

烟酸单核苷酸已被用作烟酰胺腺嘌呤二核苷酸(NAD)生物合成过程中NMN / NaMN腺苷转移酶(NMNAT)的底物。

生化/生理作用

烟酸单核苷酸(NaMN)可用于研究酵母中磷酸盐响应信号(PHO)途径与烟碱腺嘌呤二核苷酸(NAD(+))代谢之间的关系。 烟酸酯单核苷酸是NMN / NaMN腺苷转移酶(NMNAT)和烟酸酯单核苷酸腺苷转移酶的底物。NaMN酰胺化导致烟酰胺单核苷酸(NMN)的合成,其可进一步转化为NAD辅因子。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Kazuo Yamada et al.
Analytical biochemistry, 352(2), 282-285 (2006-04-01)
We have developed a liquid chromatographic-tandem mass spectrometric method that is sensitive and specific and that simultaneously measures cellular NAD(+) and related compounds. Using this method, NAD(+), NAAD, NMN, NAMN, NAM, NA, ADPR, and 5'AMP were first separated over a
William B Black et al.
Microbial cell factories, 19(1), 150-150 (2020-07-29)
Noncanonical redox cofactors are emerging as important tools in cell-free biosynthesis to increase the economic viability, to enable exquisite control, and to expand the range of chemistries accessible. However, these noncanonical redox cofactors need to be biologically synthesized to achieve
V Sharma et al.
Structure (London, England : 1993), 6(12), 1587-1599 (1998-12-24)
. Mycobacterium tuberculosis is the single most deadly human pathogen and is responsible for nearly three million deaths every year. Recent elucidation of the mode of action of isoniazid, a frontline antimycobacterial drug, suggests that NAD metabolism is extremely critical
J C Eads et al.
Structure (London, England : 1993), 5(1), 47-58 (1997-01-15)
Quinolinic acid (QA) is a neurotoxin and has been shown to be present at high levels in the central nervous system of patients with certain diseases, such as AIDS and meningitis. The enzyme quinolinic acid phosphoribosyltransferase (QAPRTase) provides the only
Determining NAD synthesis in erythrocytes.
V Micheli et al.
Methods in enzymology, 280, 211-221 (1997-01-01)

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