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N3143

Sigma-Aldrich

萘啶酸 钠盐

powder

同義詞:

1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸 钠盐

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About This Item

經驗公式(希爾表示法):
C12H11N2NaO3
CAS號碼:
分子量::
254.22
Beilstein:
3580062
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

無菌

γ-irradiated

形狀

powder

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

DNA synthesis | interferes
enzyme | inhibits

SMILES 字串

[Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12

InChI

1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1

InChI 密鑰

ROKRAUFZFDQWLE-UHFFFAOYSA-M

尋找類似的產品? 前往 產品比較指南

一般說明

Chemical structure: quinolone

應用

Recommended for use in molecular biology applications at 15 μg/ml

生化/生理作用

萘啶酸钠盐是细菌 DNA 聚合酶(DNA 旋转酶)和禽髓母细胞瘤病毒逆转录酶的抑制剂。在 酿酒酵母中抑制核酸和蛋白质合成。

重構

Prepare stock solutions directly in the vial with sterile water (5-50 mg/ml). Stock solutions should be stored at −20 °C.

取代透過

產品號碼
描述
訂價

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

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Jing Wang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14631-14644 (2020-09-13)
During spaceflight, astronauts are subjected to various physical stressors including microgravity, which could cause immune dysfunction and thus potentially predispose astronauts to infections and illness. However, the mechanisms by which microgravity affects innate immunity remain largely unclear. In this study
Robert J Commons et al.
The Medical journal of Australia, 196(5), 332-336 (2012-03-22)
To determine incidence and trends in antibiotic resistance in Australian Salmonella enterica subspecies enterica serovars Typhi (S. Typhi) and Paratyphi (S. Paratyphi) isolates over the past 26 years. A retrospective analysis of consecutive microbiologically confirmed enteric fever isolates. All S.
Migla Miskinyte et al.
Antimicrobial agents and chemotherapy, 57(1), 189-195 (2012-10-24)
Mutations causing antibiotic resistance usually incur a fitness cost in the absence of antibiotics. The magnitude of such costs is known to vary with the environment. Little is known about the fitness effects of antibiotic resistance mutations when bacteria confront
Dimitrios Farmakiotis et al.
Journal of travel medicine, 20(1), 17-21 (2013-01-03)
Typhoid is a leading cause of fever in returning travelers. The prevalence is highest in migrants visiting friends and relatives (VFR travelers) in the Indian subcontinent, where reports of resistance have been of concern. This study is a retrospective analysis
Anna Duse et al.
Journal of dairy science, 98(9), 6387-6398 (2015-07-21)
Quinolone resistance may emerge in gut bacteria (e.g., in Escherichia coli) of animals. Such bacteria could cause infections in the animal itself or be transmitted to humans via the food chain. Quinolone resistance is also observed in fecal E. coli

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