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重要文件

N171

Sigma-Aldrich

NBQX 水合物

powder, ≥98% (HPLC)

同義詞:

1,2,3,4-四氢-6-硝基-2,3-二氧代苯并[f]喹喔啉-7-磺酰胺 水合物, FG 9202

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About This Item

經驗公式(希爾表示法):
C12H8N4O6S · xH2O
CAS號碼:
分子量::
336.28 (anhydrous basis)
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

methanol: 0.25 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.5 mg/mL
DMSO: 4 mg/mL
H2O: insoluble

SMILES 字串

O.NS(=O)(=O)c1cccc2c3NC(=O)C(=O)Nc3cc([N+]([O-])=O)c12

InChI

1S/C12H8N4O6S.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);1H2

InChI 密鑰

VOYWRRFTJLCIEL-UHFFFAOYSA-N

一般說明

NBQX [2,3-二羟基-6-硝基-7-氨基磺酰基苯并(F)喹喔啉]是一种竞争性拮抗剂,其对2-氨基-3-羟基-5-甲基-4-异恶唑丙酸( AMPA)受体的亲和力要比钾盐镁矾受体高。[1]

應用

NBQX 水合物已用于:
  • 作为非NN-甲基-D-天冬氨酸受体 (NMDA)的 2-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA) 受体拮抗剂用于监测促性腺激素反应[2]
  • α单核细胞中的-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体 (AMPAR) 拮抗剂[3]
  • 在表达氯化钾共转运蛋白(shKCC2)的迁移中间神经元中的AMPA 和 N-甲基-D-天冬氨酸受体 (NMDA) 拮抗剂 [4]

生化/生理作用

NBQX [2,3-二羟基-6-硝基-7-氨基磺酰基苯并(F)喹喔啉]是一种抗惊厥药,[1]可防止脊髓挤压伤中的白质损伤,并在实验性自身免疫性脑脊髓炎(EAE)中保护少突胶质细胞。然而,其在预防EAE中炎症的作用尚不清楚。[5]
神经保护AMPA/红藻氨酸谷氨酸受体拮抗剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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