MSST0006

SILu^™Lite VEGFA Vascular endothelial growth factor A human

recombinant, expressed in HEK 293 cells, MS Protein Standard

• 同義詞: SILuLite Vascular endothelial growth factor A
• 分類程式碼代碼: 23201100
• NACRES: NA.12

屬性

• 生物源: human
• 品質等級: 200
• 重組細胞: expressed in HEK 293 cells
• 化驗: ≥98% (SDS-PAGE)
• 形狀: lyophilized powder
• 技術: mass spectrometry (MS): suitable
• UniProt登錄號: P15692
• 儲存溫度: −20°C
• 基因資訊: human ... VEGFA(7422)

描述

一般說明

SILu^™ Lite VEGF165 is a recombinant glycosylated human protein expressed in human 293 cells. It is a homodimer with an apparent molecular mass of 45 kDa.


Suggested Quantitative Analysis Parameters
(MRM settings provided for three suggested peptides)

生化／生理作用

VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure.¹ VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.²
VEGF has also been implicated in correlation with poor prognosis in breast cancer.² In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries)^3,4

序列

APMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGC

外觀

Supplied as a lyophilized powder containing phosphate buffered saline

法律資訊

SILu is a trademark of Sigma-Aldrich Co. LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable