MAK202

组织蛋白酶 S 抑制剂筛选试剂盒

Sufficient for 100 Fluorometric tests

• 同義詞: CTSS抑制剂检测试剂盒
• 分類程式碼代碼: 12352200

屬性

• 檢測方法: fluorometric
• 相關疾病: endocrinological disorders, diabetes; cardiovascular diseases; cancer
• 儲存溫度: −20°C
• 基因資訊: human ... CTSS(1520) ; mouse ... CTSS(13040) ; rat ... CTSS(50654)

描述

一般說明

Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.

適合性

适于筛选组织蛋白酶S的抑制剂。

原則

The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λ_ex = 400/ λ_em = 505 nm), proportional to the enzymatic activity present.

僅套裝組件

• CTSS Reaction Buffer
• Cathepsin S, human
• CTSS Substrate, Z-VVR-AFC, 10 mM
• CTSS Inhibitor Z-FF-FMK, 1 mM

安全資訊

• 儲存類別代碼: 10 - Combustible liquids