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MAK099

Sigma-Aldrich

谷氨酸脱氢酶(GDH)活性检测试剂盒

sufficient for 100 colorimetric tests

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About This Item

分類程式碼代碼:
12161503
NACRES:
NA.84
暫時無法取得訂價和供貨情況

用途

sufficient for 100 colorimetric tests

檢測方法

colorimetric

相關疾病

cancer; gastrointestinal diseases

儲存溫度

−20°C

基因資訊

human ... GLUD1(2746) , GLUD2(2747)
mouse ... GLUD1(14661)
rat ... GLUD1(24399)

一般說明

谷氨酸脱氢酶 (GDH) 是一种线粒体酶，催化谷氨酸可逆性氧化脱氨生成 α-酮戊二酸，作为合成代谢和分解代谢途径之间的关键链接。在哺乳动物中，GDH受变构调节，在肝脏、肾脏、大脑和胰腺中具有较高的活性。[1]血清中的 GDH 活性可用于区分肝脏炎症所致的肝脏疾病（未显示血清 GDH 活性升高）和导致肝细胞坏死的疾病（导致血清 GDH 升高）。[2]

應用

谷氨酸脱氢酶 (GDH) 活性测定试剂盒已用于测定谷氨酸脱氢酶的酶活性。[3][4]

特點和優勢

与高通量处理系统兼容。

適合性

适用于检测血清或组织及细胞提取液中的谷氨酸脱氢酶 (GDH) 活性。

原則

通过偶联酶试验可测定 GDH 活性，其中谷氨酸被 GDH 消耗，生成 NADH，NADH 与探针反应生成与 GDH 活性成比例的比色 (450 nm) 产物。一个单位的GDH 在37℃下pH 7.6 时 每分钟将产生1.0μ摩尔NADH的酶量。

取代透過

產品號碼
描述
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儲存類別代碼

10 - Combustible liquids

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
8J29K07290
8J22K07290
8C16K07290
6M17K07290
6K15K07290

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The glutamate dehydrogenase pathway and its roles in cell and tissue biology in health and disease.
Plaitakis A, et al.
Biology, 6(1), 11-11 (2017)
Tongxin Wang et al.
Animal nutrition (Zhongguo xu mu shou yi xue hui), 4(3), 329-337 (2018-09-04)
The liver is the most essential organ for the metabolism of ammonia, in where most of ammonia is removed by urea and glutamine synthesis. Regulated by leucine, glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of glutamate to ammonia. To determine
Is liver enzyme release really associated with cell necrosis induced by oxidant stress?.
Contreras-Zentella M L and Hernandez-Mu?oz R
Oxidative Medicine and Cellular Longevity, 2016 (2016)
Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4.
Castex J, et al.
Cell Death & Disease, 8(2), e2631-e2631 (2017)
Ian Monroe et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 228, 29-34 (2018-11-06)
Fathead minnows, Pimephales promelas, are found throughout the continental United States in waters in which salinity can change with tides and temperatures vary seasonally. They have been used extensively in studies of environmental toxicology and are commercially important. In a
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