M7070

Anti-MO25 兔抗

~2 mg/mL, affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-CAB39, Anti-CGI-66, Anti-Calcium binding protein 39
• 分類程式碼代碼: 12352203
• NACRES: NA.44

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~40 kDa
• 物種活性: human, rat, mouse
• 包裝: antibody small pack of 25 μL
• 加強驗證: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~2 mg/mL
• 技術: western blot: 0.5-1 μg/mL using HEK-293T cells expressing human MO25 and PC12 cell lysates
• UniProt登錄號: Q9Y376
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CAB39(51719) ; mouse ... Cab39(12283) ; rat ... Cab39(301574)

描述

一般說明

MO25 (mouse protein 25) is also termed calcium binding protein 39, CAB39 and CGI-66 is an Armadillo repeat domain scaffolding protein.

MO25 is a 40 kDa scaffolding protein that interacts with STRADα and LKB1 to regulate tumor suppression. MO25 activates LKB1 and also localizes LKB1 in the cytoplasm .

特異性

Anti-MO25 antibody is specific for MO25 in humans, rats and mice. In immunoblotting, staining of the MO25 band is specifically inhibited by the immunizing peptide.

免疫原

synthetic peptide corresponding to amino acids 308-326 located near the C-terminus of human MO25. This sequence is identical in mouse, rat, dog, and bovine MO25.

應用

Anti-MO25 antibody is suitable for use in western blot (0.5-1 μg/mL using HEK-293T cells expressing human MO25 and PC12 cell lysates).

Anti-MO25 antibody produced in rabbit has been used in western blotting.

生化／生理作用

MO25 (mouse protein 25) binds to Liver kinase B1 (LKB1) and STE20-related kinase adaptor (STRAD) and activates LKB1 and anchors it in the cell cytosol. LKB1 is a key regulator of AMP activated protein kinase (AMPK), which is a master regulator of cellular energy.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.