推薦產品
起源
Shionogi
SMILES 字串
Cc1cccc(Nc2ccccc2C(O)=O)c1C
InChI
1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
InChI 密鑰
HYYBABOKPJLUIN-UHFFFAOYSA-N
基因資訊
human ... PTGS1(5742) , PTGS2(5743)
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應用
甲芬那酸已被用于：
- 测试其在转基因斑马鱼细胞系（LiPan）中的肝脏毒性作用
- 测试其在斑马鱼胚胎/幼体中的神经保护功能
- 在水凝胶微珠中制备粘膜粘附微粒。
一种 NSAID。避免 MRP 介导的多药耐药。特异性且显著增强了蒽环类药物以及替尼泊苷、VP-16 和长春新碱的细胞毒性。
生化／生理作用
甲芬那酸是一种止痛消炎药。它可作为环氧合酶（COX）的抑制剂。它具有肝毒性，并与肝损伤有关。相反，甲芬那酸通过抑制谷氨酸盐诱导的细胞毒性，在体内缺血性中风模型中引起神经保护作用。由于对前列腺素合成的抑制作用，甲草胺可用于减轻水肿和疼痛。
特點和優勢
该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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