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Merck
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重要文件

M2922

Sigma-Aldrich

3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

同義詞:

CL 218,872

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About This Item

經驗公式(希爾表示法):
C13H9F3N4
CAS號碼:
分子量::
278.23
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:

儲存溫度

2-8°C

SMILES 字串

Cc1nnc2ccc(nn12)-c3cccc(c3)C(F)(F)F

生化/生理作用

Selective agonist at the BZI benzodiazepine receptor.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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J Karolak-Wojciechowska et al.
Bioorganic & medicinal chemistry, 2(8), 773-779 (1994-08-01)
Electronic parameters (molecular electrostatic potential MEP, charge distribution on the nitrogen atoms, dipole moment mu and ionization potential IP) were calculated by semiempirical quantum chemistry methods for 2 sets (X = H and m-CF3, the syn- and anti-rotamers of the
R K McNamara et al.
Epilepsy research, 16(1), 19-26 (1993-09-01)
To clarify the role of benzodiazepine receptors in kindling, the present experiment assessed the effects of CL 218,872 (1, 5, 10, and 20 mg/kg), a triazolopyridazine with a selective affinity for the putative benzodiazepine BZ1 receptor subtype, on the development
R L Hyson et al.
Journal of molecular neuroscience : MN, 8(3), 193-205 (1997-06-01)
Neurons in nucleus magnocellularis (NM) and nucleus laminaris (NL) of the chick brainstem auditory system show an unusual physiological response to GABA. Examination of these nuclei using in situ hybridization for GABAA receptor subunits showed a differential expression of the
D March et al.
European journal of pharmacology, 236(2), 333-336 (1993-05-19)
We have investigated the relative distributions of type I and type II benzodiazepine receptors in fetal, neonatal and adult human visual cortex using [3H]flunitrazepam and the triazolopyridazine, CL218872. Microdensitometry of autoradiograms show that while both benzodiazepine subtypes are found in
D Benke et al.
The Journal of biological chemistry, 269(43), 27100-27107 (1994-10-28)
Native gamma-aminobutyric acid type A (GABAA) receptors containing different beta-subunit variants were identified immunobiochemically with antisera recognizing selectively the beta 1-, beta 2-, or beta 3-subunit. As determined by immunoprecipitation, the beta 2-subunit was present in 55-60% of GABAA receptors

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