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重要文件

M1537

Sigma-Aldrich

微囊藻素 RR 来源于藻类

≥90% (HPLC), solid

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About This Item

經驗公式(希爾表示法):
C49H75N13O12
CAS號碼:
分子量::
1038.20
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

生物源

microbial (Microcystis aerguinosa)

品質等級

化驗

≥90% (HPLC)

形狀

solid

分子量

~_1.0 kDa

顏色

white

溶解度

ethanol: water (1:1): 0.50 mg/mL

儲存溫度

−20°C

SMILES 字串

COC(Cc1ccccc1)C(C)\C=C(C)\C=C\C2NC(=O)C(CCCNC(N)=N)NC(=O)C(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(C)NC(=O)C(=C)N(C)C(=O)CCC(NC(=O)C2C)C(O)=O)C(O)=O

InChI

1S/C49H75N13O12/c1-26(24-27(2)37(74-8)25-32-14-10-9-11-15-32)18-19-33-28(3)40(64)60-36(46(70)71)20-21-38(63)62(7)31(6)43(67)56-30(5)42(66)59-35(17-13-23-55-49(52)53)45(69)61-39(47(72)73)29(4)41(65)58-34(44(68)57-33)16-12-22-54-48(50)51/h9-11,14-15,18-19,24,27-30,33-37,39H,6,12-13,16-17,20-23,25H2,1-5,7-8H3,(H,56,67)(H,57,68)(H,58,65)(H,59,66)(H,60,64)(H,61,69)(H,70,71)(H,72,73)(H4,50,51,54)(H4,52,53,55)/b19-18+,26-24+/t27-,28-,29-,30+,33-,34-,35-,36+,37-,39+/m0/s1

InChI 密鑰

JIGDOBKZMULDHS-UUHBQKJESA-N

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生化/生理作用

Inhibitor of protein phosphatase 2A with lower toxicity than microcystin LR.
Treatment of tilapia fish with microcystin RR caused an increase in acid and alkaline phosphatases and resulted in significant renal and liver damage. [1]

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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分析證明 (COA)

Lot/Batch Number

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Loyda Atencio et al.
Toxicologic pathology, 36(3), 449-458 (2008-04-29)
Microcystins (MC) are frequently present in cyanobacterial blooms in rivers and lakes, increasing the risk of toxicity to both animals and humans. There more than eighty reported microcystins, and the present study was undertaken to determine whether MC-LR and MC-RR
M Sathishkumar et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 45(14), 1877-1884 (2010-10-19)
Microcystins (cyclic heptapeptides), produced by a number of freshwater cyanobacteria, are of health concern in potable water supplies. In this article, the adsorptive removal of microcystin-RR (MCRR) from the aqueous solution by a low-cost adsorbent, peat, was investigated. The BET
Hai Yan et al.
Chemosphere, 87(1), 12-18 (2011-12-20)
Enzymes encoded by genes biodegrading microcystins (MCs) can help reveal the function of genes and biodegradation pathway of MCs. Here the first and important gene (USTB-05-A, 1,008 bp) involved in biodegradation of microcystin-RR (MC-RR) was cloned from Sphingopyxis sp. USTB-05
M Shirai et al.
Applied and environmental microbiology, 57(4), 1241-1245 (1991-04-01)
All samples of cyanobacterial blooms collected from 1986 to 1989 from Lake Kasumigaura, Ibaraki Prefecture, Japan, were hepatotoxic. The 50% lethal doses (LD50s) of the blooms to mice ranged from 76 to 556 mg/kg of body weight. Sixty-eight Microcystis cell
Laiyan Wu et al.
Bulletin of environmental contamination and toxicology, 90(3), 382-386 (2012-12-29)
Tissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 μg g(-1) DW) was 4 times of that in liver (0.063 μg g(-1)

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