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Merck
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重要文件

L8170

Sigma-Aldrich

土槿乙酸 B

≥98% (HPLC)

同義詞:

O-土荆皮甲酸C, 土槿乙酸B, 土槿皮乙酸B

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About This Item

經驗公式(希爾表示法):
C23H28O8
CAS號碼:
分子量::
432.46
MDL號碼:
分類程式碼代碼:
12352106
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

Larix kaempferi

化驗

≥98% (HPLC)

形狀

powder or crystals

儲存條件

protect from light

顏色

white to off-white

溶解度

methanol: 1 mg/mL, clear, colorless

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

2-8°C

SMILES 字串

O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1

InChI

1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1

InChI 密鑰

XRLYZNSOXNPKOR-CBDALDGHSA-N

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生化/生理作用

土槿皮中分离得到天然二萜类化合物土槿皮乙酸B。它已显示出抗真菌,抗生育和抗血管生成特性。它还可能具有抗癌和抗炎特性。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Pauline Chiu et al.
Natural product reports, 27(7), 1066-1083 (2010-04-21)
The pseudolaric acids are diterpenoids isolated from the root bark of Pseudolarix amabilis, or the golden larch. Pseudolaric acids A and B are the major antifungal and anti-angiogenic congeners of this family of compounds. This review presents the results of
Xia Mai et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(22), 3467-3471 (2013-02-05)
To study the effect of pseudolaric acid B (PLAB) on cell proliferation and cycle of human prostate carcinoma DU-145 cells. method: Its inhibitory effect on the cell growth was measured by MTT method. Characteristics of cell death were determined by
Jing-hua Yu et al.
Acta pharmacologica Sinica, 29(9), 1069-1076 (2008-08-23)
To investigate the apoptotic mechanism of pseudolaric acid B (PAB) in human breast cancer MCF-7 cells. 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide analysis and morphological changes were applied to detect apoptosis. The percentage of apoptotic and necrotic cells were calculated by the lactate
Tan Li et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45(5), 668-676 (2012-01-24)
Pseudolaric acid B (PAB) is a novel diterpenoid, isolated from Pseudolarix kaempferi Gorden, which roots are widely used to treat inflammatory and microbial skin diseases for centuries, but the underlying mechanism remains elusive. To address the immunoregulatory mechanisms of PAB
Jinghua Yu et al.
Journal of pharmacological sciences, 107(3), 295-302 (2008-07-19)
Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%

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