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L2887

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0128:B12

purified by gel-filtration chromatography

同義詞:

LPS

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About This Item

EC號碼:
MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

Escherichia coli (O128:B12)

品質等級

形狀

lyophilized powder

純化經由

gel-filtration chromatography

雜質

<1% Protein

顏色

white to light yellow

溶解度

water: soluble

運輸包裝

ambient

儲存溫度

2-8°C

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一般說明

该产品是从大肠埃希菌血清型O128:B12中提取,并经凝胶过滤纯化。源菌株为CDC 2440-69。

應用

脂多糖(LPS)是革兰氏阴性菌细胞壁的特征性成分。LPS及其脂质A部分可通过Toll样受体4(TLR4)刺激先天免疫系统细胞,TLR4是Toll样受体蛋白家族的成员,它能识别常见的病原体相关分子模式(PAMP)。

生化/生理作用

脂多糖(LPS)位于膜的外层,并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性,并保护细胞免受胆汁盐和亲脂性抗生素的破坏。

準備報告

本品溶于水(5 mg/ml)或细胞培养基(1 mg/ml),得到浑浊的淡黄色溶液。以盐水为溶剂时,经过涡旋并加热至70-80 oC后,得到浓度更高但仍然浑浊的溶液(20 mg/ml)。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中,可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液,而以水为溶剂将得到均匀的混浊溶液。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

相關產品

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Yulia Kiyan et al.
Frontiers in immunology, 11, 573550-573550 (2020-12-29)
GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood. In this study we demonstrate that uPAR is a part of Toll-like
Hana M Zegallai et al.
bioRxiv : the preprint server for biology (2021-11-04)
Barth Syndrome (BTHS) is a rare X-linked genetic disorder caused by mutation in the TAFAZZIN gene which encodes the cardiolipin (CL) transacylase tafazzin (Taz). Taz deficiency in BTHS patients results in reduced CL in their tissues and a neutropenia which
Tian-Yong Hu et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 55, 214-221 (2019-01-23)
Swertia chirayita, has been commonly used under the name "Zang-yin-chen" for the treatment of liver infections, inflammation, abdominal pain, and bacterial infection in traditional Tibetan medicine. However, the bioactive components with anti-inflammatory activities and underlying mechanisms remain poorly evaluated. Repeated
Fan He et al.
Molecular medicine reports, 19(3), 1443-1452 (2019-01-11)
The present study aimed to investigate the effects of low‑dose lipopolysaccharide (LPS) on ischemia/reperfusion (I/R)‑induced brain injury, and to explore the mechanism of phosphoinositide 3‑kinase (PI3K)/Akt/forkhead box protein (Fox)O1 signaling pathway. Male Sprague‑Dawley rats were divided into control group (control)
Tian-Yong Hu et al.
Journal of inflammation research, 14, 587-597 (2021-03-06)
Marine natural products harbor a variety of pharmacological activities, and the sea species have been becoming a main source of new drug candidate. In pursuit of safer and more effective anti-inflammation drug, the anti-inflammatory activities, anti-oxygenation effects and underlying molecular

文章

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

相關內容

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

脂多醣 (LPS) 是革蘭氏陰性細菌的主要成分,對微生物研究非常重要。

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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