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重要文件

I141

Sigma-Aldrich

脂肪乳

emulsion, lipid emulsion

同義詞:

磷脂稳定大豆油

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.77
暫時無法取得訂價和供貨情況

產品名稱

脂肪乳, 20%, emulsion

形狀

emulsion

品質等級

濃度

20%

顏色

white

儲存溫度

2-8°C

應用

内脂内用于:
  • 测试其用作组织体模生成散射介质时的光学性质[1]
  • 作为降低散射系数和背景吸光度的琼脂糖凝胶体模组分在高胰岛素-正常血糖钳研究中,[2]
  • 输注至小鼠体内输注以评估其对非酯化游离脂肪酸(NEFA)循环的影响[3]

生化/生理作用

脂质内是由大豆油组成的脂质乳剂。其具有有助生成促炎细胞因子的作用,建议用于免疫介导的妊娠和植入失败治疗。[4]在肠胃外营养方面,脂质内是脂肪来源。[5]它通过抑制线粒体膜通透性转变孔开启,避免心脏缺血再灌注损伤。[6] 内脂内是静脉免疫球蛋白的有效替代品,可提高铂基抗癌药的生物利用度。[7]

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves


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分析證明 (COA)

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Birgitta I Zielbauer et al.
Journal of colloid and interface science, 529, 197-204 (2018-06-13)
Oleosomes are stabilized by a complex outer phospholipid-protein-layer. To improve understanding of its structure and stabilization mechanism, this shell has to be studied in extracellular native conditions. This should be possible by SANS using contrast variation. Oleosomes are expected to
Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A
Li J, et al.
Anesthesiology, 117(4), 836-846 (2012)
Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice
Xu W, et al.
Molecular and Cellular Endocrinology, 482(22), 1-10 (2019)
Benedict Mc Larney et al.
Journal of biophotonics, 12(6), e201800387-e201800387 (2019-02-01)
Accurate image reconstruction in volumetric optoacoustic tomography implies the efficient generation and collection of ultrasound signals around the imaged object. Non-uniform delivery of the excitation light is a common problem in optoacoustic imaging often leading to a diminished field of
Lisa R Beutler et al.
eLife, 9 (2020-07-29)
Body weight is regulated by interoceptive neural circuits that track energy need, but how the activity of these circuits is altered in obesity remains poorly understood. Here we describe the in vivo dynamics of hunger-promoting AgRP neurons during the development

Questions

1–10 of 11 Questions  
  1. Hi I did use freeze-dry to convert intralipid to powder but what I have now is liquid, I was wondering that the intralipid is water base or oil base? because that makes difference in my research. Thnaks

    1 answer
    1. This product, Intralipid, is a lipid emulsion comprising soybean oil.

      Helpful?

  2. I need to prepare a 500 ml phantom using Intralipid 20% and distilled water. How much Intralipid 20% should I add to the distilled water to achieve a reduced scattering coefficient of 8 cm−1?

    1 answer
    1. Unfortunately, the scattering coefficient of this material has not been determined. The scattering coefficient of Intralipid 20% can vary due to differences in the concentrations of soybean oil, glycerin, phospholipids, free fatty acids, and pH between batches. Regarding the determination of the scattering coefficient in distilled water and establishing a reference value, the following citation from Biomedical Optics Express (2021) may be of interest.
      Biomed Opt Express. 2021 Oct 7;12(11):6814-6830.
      Investigation of methods to extract confocal function parameters for the depth-resolved determination of attenuation coefficients using OCT in intralipid samples, titanium oxide phantoms, and in vivo human retinas
      https://pubmed.ncbi.nlm.nih.gov/34858682/

      Helpful?

  3. Hi. Do you know what is extinction coefficient at 680 nm and molecular weight of this product? Thank you

    1 answer
    1. Unfortunately, the extinction coefficient is not determined for this product. This is a multi-component material containing a range of fatty acids and phospholipids, the molecular weight is not available.

      Helpful?

  4. Hello, I am using IL-20 for tissue phantoms. Is the 20% concentration a volume/volume concentration or something different?

    1 answer
    1. The concentration is specified as 20% weight/weight (w/w).

      Helpful?

  5. Is this solution sterile?

    1 answer
    1. Yes. Intralipid 20% is a sterile product. The product is sterilized in its final container.

      Helpful?

  6. Is there a concentration for Intralipid 20% in mg/mL? Or a density value in order to calculate concentration in mg/mL?

    1 answer
    1. The density of Intralipid, 20% is 0.99 g/mL at room temperature. The "20%" in the product name is a nominal value; the specification for the concentration is 18.0 to 22.0 percent on a weight-to-weight basis. Based on a density of 0.99 g/mL, that would convert to a weight-to-volume percentage of soybean oil of 17.8 to 21.8 percent, or 178-218 g/mL.

      Please navigate to the DOCUMENTATION section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:
      https://www.sigmaaldrich.com/product/sigma/i141#product-documentation

      Helpful?

  7. Is there a shelf life for this product or after opening?

    1 answer
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

  8. Can Product I141, Intralipid, be used in cell culture?

    1 answer
    1. We have not tested this product for cell culture application. An article by Per Oscarsson, A., et al., Acta Anaesthesiol. Scand. 45, 1215-1220 (2001), used Intralipid in cell culture with primary cultured rat neurons at 1.0 mg/mL for 20 minutes.

      Helpful?

  9. What are the components of Product I141, Intralipid?

    1 answer
    1. This Intralipid is made up of 20% soybean oil, 1.2% egg yolk phospholipids and 2.25% glycerin; the remainder is water.

      Helpful?

  10. How should Product I141, Intralipid, be stored?

    1 answer
    1. This product should be stored tightly sealed at 2-8°C.

      Helpful?

1–10 of 11 Questions  

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