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Merck
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HPA029874

Sigma-Aldrich

Anti-CAMP antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

同義詞:

Anti-CAP18, Anti-FALL-39, Anti-FALL39, Anti-LL37, Anti-cathelicidin antimicrobial peptide

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
人類蛋白質圖譜編號:
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

產品線

Prestige Antibodies® Powered by Atlas Antibodies

形狀

buffered aqueous glycerol solution

物種活性

human

加強驗證

orthogonal RNAseq
Learn more about Antibody Enhanced Validation

技術

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:2500-1:5000

免疫原序列

RSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPR

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CAMP(820)

一般說明

CAMP (cationic antimicrobial peptide) is a necessary component of human innate immunity. It is also known as LL-37 (antimicrobial peptide). It is produced by various cells, including epithelial cells, keratinocytes, and neutrophils. CAMPs are designated by α- and β-defensins and the cathelicidin-derived LL-37 peptide. It is mostly present in microenvironments, that foster carbamylation. It is located on chromosome 3p21.

免疫原

cathelicidin antimicrobial peptide recombinant protein epitope signature tag (PrEST)

應用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-CAMP has been used in IF (immunofluorescence) and in immunohistochemistry.

生化/生理作用

CAMP (cationic antimicrobial peptides) kills a wide spectrum of pathogenic bacteria. It neutralizes LPS (lipopolysaccharide), and act as a chemoattractant for immune cells including T cells, monocytes, neutrophils, and mast cells. It enormously affects the direction of dendritic cell maturation, activates production of cytokines, chemokines, and their receptors and stimulates mast cell degranulation. Its major role is to act as a signaling molecule for innate and acquired immunity.

特點和優勢

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

聯結

Corresponding Antigen APREST72145

外觀

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

法律資訊

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Carbamylated LL-37 as a modulator of the immune response
Koro C, et al.
Innate Immunity, 22(3), 218-229 (2016)
Tiziana Cubeddu et al.
Veterinary immunology and immunopathology, 189, 66-70 (2017-07-04)
Cathelicidins are well-characterized antimicrobial peptides (AMPs) that are present in significant amounts in mastitic milk. Neutrophils are believed to be the main producers of these AMPs, while the role of mammary epithelial cells (MECs) in their production and release is
Polymorphism in cathelicidin gene (CAMP) that alters Hypoxia-inducible factor (HIF-1?::ARNT) binding is not associated with tuberculosis
Lopez Campos GN
International Journal of Immunogenetics, 41(1), 54-62 (2014)

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