MABS1136

Anti-Cathelicidin/FALL-39/LL-37 Antibody, clone 8C10.1

clone 8C10.1, from mouse

• 同義詞: Cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein, CAP-18, hCAP-18
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 8C10.1, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_004336
• UniProt登錄號: P49913
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CAMP(820)

描述

一般說明

Cathelicidin antimicrobial peptide (UniProt P49913; also known as 18 kDa cationic antimicrobial protein, CAP-18, hCAP-18) is encoded by the CAMP (also known as CAP18, FALL39, LL37) gene (ORF HSD26; Gene ID 820) in human. The human cathelicidin antimicrobial protein 18 (hCAP-18) is initially translated as a precursor molecule with a signal peptide (a.a. 1-30) and a propeptide (a.a. 31-131) sequence, the removal of which yields the mature hCAP-18 (a.a. a.a. 132-173). During the inflammatory response, hCAP-18 is proteolytically cleaved into the FALL-39 (a.a 132-170), which is further processed to yield the antimicrobial protein LL-37 (CAP-37; a.a. 134-170). Neutrophils store preformed hCAP-18 within specific granules and release it into inflamed tissue as a result of granule exocytosis. Once released, hCAP-18 is activated by proteinase-3-mediated cleavage, a component of neutrophil primary granules. In addition to its microbicidal and LPS-sequestering activity, LL-37 is also involved in the regulation of innate and humoral immune responses, wound healing, and tissue repair.

特異性

Clone 8C10.1 targets a C-terminal epitope present in the prepro- (a.a. 1-173) and pro- (a.a. 31-173) forms of hCAP-18, as well as the processed antibacterial peptides FALL-39 (a.a 132-170) and LL-37 (a.a. 134-170), but not the preprodomain (a.a. 1-131) or prodomain (a.a. 31-131) fragment.

免疫原

Epitope: C-terminal.

KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Cathelicidin/FALL-39/LL-37.

應用

Anti-Cathelicidin Antibody, clone 8C10.1 is an antibody against Cathelicidin/FALL-39/LL-37 for use in Immunohistochemistry.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Cathelicidin/FALL-39/LL-37 immunoreactivity in human spleen tissue sections.

Research Category
Signaling

Research Sub Category
Inflammation & Autoimmune Mechanisms

品質

Evaluated by Immunohistochemistry in human bone marrow tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Cathelicidin/FALL-39/LL-37 immunoreactivity in human bone marrow tissue sections.

標靶描述

19.30 kDa (prepro-hCAP-18), 16.02 kDa (pro-hCAP-18), 4.712 kDa (FALL-39; a.a. 132-170) and 4.493 kDa (LL-37; a.a. 134-170) calculated.

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable