The product looks to be soluble in DMSO ~2mg/mL according to different sources. MilliporeSigma only has information validated for ethanol and methanol.
推薦產品
產品名稱
(Z)-4-羟三苯氧胺, ≥98% Z isomer
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
protect from light
溶解度
methanol: 10 mg/mL
ethanol: 20 mg/mL (with heating)
抗生素活性譜
neoplastics
作用方式
enzyme | inhibits
起源
AstraZeneca
儲存溫度
2-8°C
SMILES 字串
CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3
InChI
1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChI 密鑰
TXUZVZSFRXZGTL-QPLCGJKRSA-N
基因資訊
human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) , IL6(3569)
rat ... Ar(24208) , Esr1(24890) , Esr2(25149)
一般說明
4-羟基他莫昔芬(4-OHT)是抗雌激素药物他莫昔芬在人和其他哺乳动物中的代谢产物。[1]Z型(反式)和E型(顺式)4-OHT异构体在未成熟大鼠中均具有抗雌激素作用。对反式的固定环(fixed ring)体系的结构-功能关系研究表明，反式异构体是一种强效抗雌激素剂，在体外T47D乳腺癌细胞中顺式异构体的抗雌激素作用相对较弱（效力低100倍）。4-OHT结合雌激素受体(ER)和雌激素相关受体(ERR)，同时具有雌激素和抗雌激素作用。这种物质是细胞渗透性的选择性雌激素受体调节剂(SERM)。与他莫昔芬和它的其他代谢物相比，4-OHT结合雌激素受体的亲和性更高，对正常人乳腺细胞和乳腺癌细胞系培养物的增殖抑制效力高50-100倍。[2]此外，对这些细胞不添加雌激素培养、通过胰岛素或表皮生长因子诱导增殖时，4-OHT可有效抑制细胞生长。
特點和優勢
该化合物由AstraZeneca开发。如需浏览其他药物开发的化合物和批准的药物/候选药物清单，请单击此处。
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
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文章
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What is the (Z)-4-Hydroxytamoxifen (product H7904) solubility in DMSO?
1 answer-
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What are the solubility and solution stability recommendations for product H7904?
1 answer-
We do not test shelf life of solutions of this product in methanol or ethanol. Solubility in 95% ethanol at 20-25 mg/ml producing a clear, very faint yellow solution. Heating is required for solubilization in ethanol (20mg/ml); it is recommended to heat the powder in the solvent for short time periods and alternately invert or vortex to stir it, repeating until product appears dissolved, to prevent over- heating of the product.
Solutions of 4-OHT were prepared in methanol or chloroform at 10 mg/ml, yielding clear solutions
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Is there Regulatory Support File available for storing product H7904 outside the recommended temperature range of 2-8°C?
1 answer-
There is no Regulatory Support File (RSF) available for storing product H7904 outside the recommended temperature range of 2-8°C. The product is not produced or offered as a compendial grade product and is strictly for research use only.
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